Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Abstract Background Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonl...

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Bibliographic Details
Main Authors: Yi-wei Wang, Qin Zhou, Xiang Zhang, Qing-qing Qian, Jia-wen Xu, Peng-fei Ni, Yan-ning Qian
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Neuroinflammation
Subjects:
Endoplasmic reticulum stress
Neuroinflammation
Microglia
Neurodegeneration
Lipopolysaccharide
Online Access:http://link.springer.com/article/10.1186/s12974-017-1002-7

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