[<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy
An increasing number of patients are living with chronic ischemic cardiomyopathy (ICM) and/or heart failure. Treatment options and prognostic tools are lacking for many of these patients. Our aim was to investigate the prognostic value of imaging angiogenesis and macrophage activation via positron e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/2/268 |
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| author | Bjarke Follin Cecilie Hoeeg Ingrid Hunter Simon Bentsen Morten Juhl Jacob Kildevang Jensen Tina Binderup Carsten Haagen Nielsen Rasmus Sejersten Ripa Jens Kastrup Annette Ekblond Andreas Kjaer |
| author_facet | Bjarke Follin Cecilie Hoeeg Ingrid Hunter Simon Bentsen Morten Juhl Jacob Kildevang Jensen Tina Binderup Carsten Haagen Nielsen Rasmus Sejersten Ripa Jens Kastrup Annette Ekblond Andreas Kjaer |
| author_sort | Bjarke Follin |
| collection | DOAJ |
| description | An increasing number of patients are living with chronic ischemic cardiomyopathy (ICM) and/or heart failure. Treatment options and prognostic tools are lacking for many of these patients. Our aim was to investigate the prognostic value of imaging angiogenesis and macrophage activation via positron emission tomography (PET) in terms of functional improvement after cell therapy. Myocardial infarction was induced in rats. Animals were scanned with [<sup>18</sup>F]FDG PET and echocardiography after four weeks and randomized to allogeneic adipose tissue-derived stromal cells (ASCs, <i>n</i> = 18) or saline (<i>n</i> = 9). Angiogenesis and macrophage activation were assessed before and after treatment by [<sup>68</sup>Ga]Ga-RGD and [<sup>64</sup>Cu]Cu-DOTATATE. There was no overall effect of the treatment. Rats that improved left ventricular ejection fraction (LVEF) had higher uptake of both [<sup>68</sup>Ga]Ga-RGD and [<sup>64</sup>Cu]Cu-DOTATATE at follow-up (<i>p</i> = 0.006 and <i>p</i> = 0.008, respectively). The uptake of the two tracers correlated with each other (r = 0.683, <i>p</i> = 0.003 pre-treatment and <i>r</i> = 0.666, <i>p</i> = 0.004 post-treatment). SUVmax at follow-up could predict improvement in LVEF (<i>p</i> = 0.016 for [<sup>68</sup>Ga]Ga-RGD and <i>p</i> = 0.045 for [<sup>64</sup>Cu]Cu-DOTATATE). High uptake of [<sup>68</sup>Ga]Ga-RGD and [<sup>64</sup>Cu]Cu-DOTATATE PET after injection of ASCs or saline preceded improvement in LVEF. The use of these tracers could improve the monitoring of heart failure patients in treatment. |
| first_indexed | 2024-03-09T13:02:41Z |
| format | Article |
| id | doaj.art-553816c9f2dd4bc9abb265082e198552 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T13:02:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-553816c9f2dd4bc9abb265082e1985522023-11-30T21:52:21ZengMDPI AGDiagnostics2075-44182023-01-0113226810.3390/diagnostics13020268[<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic CardiomyopathyBjarke Follin0Cecilie Hoeeg1Ingrid Hunter2Simon Bentsen3Morten Juhl4Jacob Kildevang Jensen5Tina Binderup6Carsten Haagen Nielsen7Rasmus Sejersten Ripa8Jens Kastrup9Annette Ekblond10Andreas Kjaer11Cardiology Stem Cell Centre, The Heart Centre, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, DenmarkCardiology Stem Cell Centre, The Heart Centre, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, DenmarkMinerva Imaging ApS, DK-3650 Oelstykke, DenmarkDepartment of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital—Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, DenmarkCardiology Stem Cell Centre, The Heart Centre, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital—Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital—Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, DenmarkMinerva Imaging ApS, DK-3650 Oelstykke, DenmarkDepartment of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital—Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, DenmarkCardiology Stem Cell Centre, The Heart Centre, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, DenmarkCardiology Stem Cell Centre, The Heart Centre, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital—Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, DenmarkAn increasing number of patients are living with chronic ischemic cardiomyopathy (ICM) and/or heart failure. Treatment options and prognostic tools are lacking for many of these patients. Our aim was to investigate the prognostic value of imaging angiogenesis and macrophage activation via positron emission tomography (PET) in terms of functional improvement after cell therapy. Myocardial infarction was induced in rats. Animals were scanned with [<sup>18</sup>F]FDG PET and echocardiography after four weeks and randomized to allogeneic adipose tissue-derived stromal cells (ASCs, <i>n</i> = 18) or saline (<i>n</i> = 9). Angiogenesis and macrophage activation were assessed before and after treatment by [<sup>68</sup>Ga]Ga-RGD and [<sup>64</sup>Cu]Cu-DOTATATE. There was no overall effect of the treatment. Rats that improved left ventricular ejection fraction (LVEF) had higher uptake of both [<sup>68</sup>Ga]Ga-RGD and [<sup>64</sup>Cu]Cu-DOTATATE at follow-up (<i>p</i> = 0.006 and <i>p</i> = 0.008, respectively). The uptake of the two tracers correlated with each other (r = 0.683, <i>p</i> = 0.003 pre-treatment and <i>r</i> = 0.666, <i>p</i> = 0.004 post-treatment). SUVmax at follow-up could predict improvement in LVEF (<i>p</i> = 0.016 for [<sup>68</sup>Ga]Ga-RGD and <i>p</i> = 0.045 for [<sup>64</sup>Cu]Cu-DOTATATE). High uptake of [<sup>68</sup>Ga]Ga-RGD and [<sup>64</sup>Cu]Cu-DOTATATE PET after injection of ASCs or saline preceded improvement in LVEF. The use of these tracers could improve the monitoring of heart failure patients in treatment.https://www.mdpi.com/2075-4418/13/2/268angiogenesisinflammationnuclear cardiologycardiomyopathycell therapy |
| spellingShingle | Bjarke Follin Cecilie Hoeeg Ingrid Hunter Simon Bentsen Morten Juhl Jacob Kildevang Jensen Tina Binderup Carsten Haagen Nielsen Rasmus Sejersten Ripa Jens Kastrup Annette Ekblond Andreas Kjaer [<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy Diagnostics angiogenesis inflammation nuclear cardiology cardiomyopathy cell therapy |
| title | [<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy |
| title_full | [<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy |
| title_fullStr | [<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy |
| title_full_unstemmed | [<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy |
| title_short | [<sup>68</sup>Ga]Ga-NODAGA-E[(cRGDyK)]<sub>2</sub> and [<sup>64</sup>Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy |
| title_sort | sup 68 sup ga ga nodaga e crgdyk sub 2 sub and sup 64 sup cu cu dotatate pet predict improvement in ischemic cardiomyopathy |
| topic | angiogenesis inflammation nuclear cardiology cardiomyopathy cell therapy |
| url | https://www.mdpi.com/2075-4418/13/2/268 |
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