Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease
Abstract Background There are inconsistent data about the role of serum phospholipid fatty acid composition in patients with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The aim of the study was to investigate the relationship between serum phospholipid fatty acid compo...
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-018-0672-5 |
| _version_ | 1811261428746682368 |
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| author | Malgorzata Poreba Pawel Rostoff Aleksander Siniarski Magdalena Mostowik Renata Golebiowska-Wiatrak Jadwiga Nessler Anetta Undas Grzegorz Gajos |
| author_facet | Malgorzata Poreba Pawel Rostoff Aleksander Siniarski Magdalena Mostowik Renata Golebiowska-Wiatrak Jadwiga Nessler Anetta Undas Grzegorz Gajos |
| author_sort | Malgorzata Poreba |
| collection | DOAJ |
| description | Abstract Background There are inconsistent data about the role of serum phospholipid fatty acid composition in patients with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The aim of the study was to investigate the relationship between serum phospholipid fatty acid composition, systemic low-grade inflammation, and glycemic control in high-risk T2DM patients. Methods Seventy-four patients (26% women, mean age 65.6 ± 6.8 years) with T2DM (median diabetes duration 10 years) and documented ASCVD (74 with coronary artery disease, 26 with peripheral arterial disease) were enrolled in the study. Baseline HbA1c was estimated using turbidimetric inhibition immunoassay. According to the median value of HbA1c the patients were grouped into those with HbA1c < 7.0% (< 53 mmol/mol) (n = 38) and those with HbA1c ≥ 7.0% (≥ 53 mmol/mol) (n = 36). Serum phospholipid fatty acids were measured with gas chromatography. Results Patients with HbA1c ≥ 7.0%, compared with those with HbA1c < 7.0% had similar composition of saturated and monounsaturated fatty acids in serum phospholipids, but had higher concentrations of linoleic acid (LA) and higher n-6/n-3 polyunsaturated fatty acid (PUFA) ratio as well as lower levels of eicosapentaenoic acid (EPA), total n-3 PUFAs, and the EPA/arachidonic acid ratio. We found that LA (r = 0.25; p = 0.03) and n-6/n-3 PUFA ratio (r = 0.28; p = 0.02) were positively correlated with HbA1c. Multivariate logistic regression analysis showed that n-6/n-3 PUFA ratio, hsCRP and T2DM duration were independent predictors of worse glycemic control in patients with T2DM and ASCVD. Conclusions This study showed that glycemic control in high-risk T2DM patients with ASCVD was significantly associated with unfavorable serum phospholipid n-6/n-3 PUFA ratio and greater systemic inflammation. |
| first_indexed | 2024-04-12T19:03:12Z |
| format | Article |
| id | doaj.art-5539926f59794b7ea480284b097d3216 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-12T19:03:12Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-5539926f59794b7ea480284b097d32162022-12-22T03:20:05ZengBMCCardiovascular Diabetology1475-28402018-02-0117111110.1186/s12933-018-0672-5Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular diseaseMalgorzata Poreba0Pawel Rostoff1Aleksander Siniarski2Magdalena Mostowik3Renata Golebiowska-Wiatrak4Jadwiga Nessler5Anetta Undas6Grzegorz Gajos7Department of Coronary Disease and Heart Failure, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalDepartment of Coronary Disease and Heart Failure, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalDepartment of Coronary Disease and Heart Failure, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalDepartment of Coronary Disease and Heart Failure, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalDepartment of Coronary Disease and Heart Failure, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalDepartment of Coronary Disease and Heart Failure, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalInstitute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalDepartment of Coronary Disease and Heart Failure, Faculty of Medicine, Jagiellonian University Medical College, The John Paul II HospitalAbstract Background There are inconsistent data about the role of serum phospholipid fatty acid composition in patients with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The aim of the study was to investigate the relationship between serum phospholipid fatty acid composition, systemic low-grade inflammation, and glycemic control in high-risk T2DM patients. Methods Seventy-four patients (26% women, mean age 65.6 ± 6.8 years) with T2DM (median diabetes duration 10 years) and documented ASCVD (74 with coronary artery disease, 26 with peripheral arterial disease) were enrolled in the study. Baseline HbA1c was estimated using turbidimetric inhibition immunoassay. According to the median value of HbA1c the patients were grouped into those with HbA1c < 7.0% (< 53 mmol/mol) (n = 38) and those with HbA1c ≥ 7.0% (≥ 53 mmol/mol) (n = 36). Serum phospholipid fatty acids were measured with gas chromatography. Results Patients with HbA1c ≥ 7.0%, compared with those with HbA1c < 7.0% had similar composition of saturated and monounsaturated fatty acids in serum phospholipids, but had higher concentrations of linoleic acid (LA) and higher n-6/n-3 polyunsaturated fatty acid (PUFA) ratio as well as lower levels of eicosapentaenoic acid (EPA), total n-3 PUFAs, and the EPA/arachidonic acid ratio. We found that LA (r = 0.25; p = 0.03) and n-6/n-3 PUFA ratio (r = 0.28; p = 0.02) were positively correlated with HbA1c. Multivariate logistic regression analysis showed that n-6/n-3 PUFA ratio, hsCRP and T2DM duration were independent predictors of worse glycemic control in patients with T2DM and ASCVD. Conclusions This study showed that glycemic control in high-risk T2DM patients with ASCVD was significantly associated with unfavorable serum phospholipid n-6/n-3 PUFA ratio and greater systemic inflammation.http://link.springer.com/article/10.1186/s12933-018-0672-5Cardiovascular diseaseAtherosclerosisType 2 diabetesGlycemic controlInflammationFatty acids |
| spellingShingle | Malgorzata Poreba Pawel Rostoff Aleksander Siniarski Magdalena Mostowik Renata Golebiowska-Wiatrak Jadwiga Nessler Anetta Undas Grzegorz Gajos Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease Cardiovascular Diabetology Cardiovascular disease Atherosclerosis Type 2 diabetes Glycemic control Inflammation Fatty acids |
| title | Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease |
| title_full | Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease |
| title_fullStr | Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease |
| title_full_unstemmed | Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease |
| title_short | Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease |
| title_sort | relationship between polyunsaturated fatty acid composition in serum phospholipids systemic low grade inflammation and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease |
| topic | Cardiovascular disease Atherosclerosis Type 2 diabetes Glycemic control Inflammation Fatty acids |
| url | http://link.springer.com/article/10.1186/s12933-018-0672-5 |
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