Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD.

Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD.

Techniques to expand human hematopoietic stem cells ex-vivo could be beneficial to the fields of clinical hematopoietic stem cell transplantation and gene therapy targeted at hematopoietic stem cells. NUP98-HOXA10HD is a relatively newly discovered fusion gene that in mouse transplant experiments ha...

Full description

Bibliographic Details
Main Authors:	Allistair Abraham, Yoon-Sang Kim, Huifen Zhao, Keith Humphries, Derek A Persons
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4711970?pdf=render

Similar Items

NUP98-HOXA10hd-Expanded Hematopoietic Stem Cells Efficiently Reconstitute Bone Marrow of Mismatched Recipients and Induce Tolerance
by: Y. Even, et al.
Published: (2011-08-01)

Spiny mice (Acomys) cells fail to engraft in NOD scid gamma.
by: Janak Gaire, et al.
Published: (2023-01-01)

Disclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach
by: Adélia Mendes, et al.
Published: (2020-07-01)

A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.
by: Gwenaëlle Gavory, et al.
Published: (2021-08-01)

The Retinoblastoma Tumor Suppressor Is Required for the NUP98-HOXA9-Induced Aberrant Nuclear Envelope Phenotype
by: Marcela Vaz, et al.
Published: (2021-10-01)

Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγnull mice treated with alogliptin
by: Jurczyk A, et al.
Published: (2013-12-01)

Long-term engraftment of human natural T regulatory cells in NOD/SCID IL2rγc(null) mice by expression of human IL-2.
by: Sojan Abraham, et al.
Published: (2012-01-01)

Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells
by: Thomas Nolte, et al.
Published: (2013-01-01)

Evaluating Human Immune Responses for Vaccine Development in a Novel Human Spleen Cell-Engrafted NOD-SCID-IL2rγNull Mouse Model
by: Stéphanie Ghosn, et al.
Published: (2018-03-01)

Genetic labelling of human bone marrow osteogenic stem cells: Differentiation potentials and engraftment into NOD/SCID mice.
by: Xia, Z, et al.
Published: (2001)

Differential post-surgical metastasis and survival in SCID, NOD-SCID and NOD-SCID-IL-2Rγ(null) mice with parental and subline variants of human breast cancer: implications for host defense mechanisms regulating metastasis.
by: Chloe C Milsom, et al.
Published: (2013-01-01)

Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition
by: Yong Dong, et al.
Published: (2019-08-01)

Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.
by: Lars Palmqvist, et al.
Published: (2007-01-01)

NOD-scid IL2R γ<sup>null</sup> mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways
by: Zadeh-Khorasani Maryam, et al.
Published: (2013-01-01)

High-titer foamy virus vector transduction and integration sites of human CD34+ cell–derived SCID-repopulating cells
by: Md Nasimuzzaman, et al.
Published: (2014-01-01)

Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes
by: Masahiro Oka, et al.
Published: (2016-01-01)

Uncleavable Nup98–Nup96 is functional in the fission yeastSchizosaccharomyces pombe
by: Haruhiko Asakawa, et al.
Published: (2015-01-01)

Amniotic mesenchymal stem cells enhance wound healing in diabetic NOD/SCID mice through high angiogenic and engraftment capabilities.
by: Sung-Whan Kim, et al.
Published: (2012-01-01)

Dynamic association of NUP98 with the human genome.
by: Yun Liang, et al.
Published: (2013-01-01)

Correction: Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities
Published: (2012-01-01)

Correction: Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities.
by: Sung-Whan Kim, et al.
Published: (2012-01-01)

Correction: Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities
Published: (2012-01-01)

Correction: Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities
Published: (2012-01-01)

Correction: Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities.
by: Sung-Whan Kim, et al.
Published: (2012-01-01)

Correction: Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities.
by: Sung-Whan Kim, et al.
Published: (2012-01-01)

Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
by: Wendy W J Unger, et al.
Published: (2012-01-01)

Assessment of benzene-induced hematotoxicity using a human-like hematopoietic lineage in NOD/Shi-scid/IL-2Rγnull mice.
by: Masayuki Takahashi, et al.
Published: (2012-01-01)

Successful establishment of an orthotopic hepatoblastoma in vivo model in NOD/LtSz-scid IL2Rγnull mice.
by: Verena Ellerkamp, et al.
Published: (2011-01-01)

Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells
by: Brian E. McIntosh, et al.
Published: (2015-02-01)

A radiolabeled antibody targeting CD123+ leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML
by: Jeffrey V. Leyton, et al.
Published: (2015-01-01)

Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse.
by: Sangeetha V M, et al.
Published: (2010-01-01)

Inhibition of KSHV-associated lymphoma engraftment in SCID mouse by morpholino oligomers
by: Zhang Yanjin, et al.
Published: (2010-10-01)

Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98
by: Lisa Diez, et al.
Published: (2022-03-01)

NUP98 Rearrangements in AML: Molecular Mechanisms and Clinical Implications
by: Sagarajit Mohanty
Published: (2023-07-01)

Nup98-dependent transcriptional memory is established independently of transcription
by: Pau Pascual-Garcia, et al.
Published: (2022-03-01)

Correction: Expansion of Cord Blood CD34+ Cells in Presence of zVADfmk and zLLYfmk Improved Their In Vitro Functionality and In Vivo Engraftment in NOD/SCID Mouse
Published: (2014-01-01)

Correction: Expansion of Cord Blood CD34 Cells in Presence of zVADfmk and zLLYfmk Improved Their In Vitro Functionality and In Vivo Engraftment in NOD/SCID Mouse.
Published: (2014-01-01)

Human osteoclastogenesis in Epstein-Barr virus-induced erosive arthritis in humanized NOD/Shi-scid/IL-2Rγnull mice.
by: Yosuke Nagasawa, et al.
Published: (2021-01-01)

Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rγnull mice display a T-effector memory phenotype.
by: Niwa Ali, et al.
Published: (2012-01-01)

The Assessment of Human Erythroid Output in NOD/SCID Mice Reconstituted with Human Hematopoietic Stem Cells
by: Jun Hayakawa, et al.
Published: (2010-11-01)