Hyperuricemia and Proteinuria in Type 2 Diabetic Patients
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has diabetic nephropathy as a complication characterized by proteinuria. When type 2 diabetic patient’s kidney is damaged, hyperuricemia occurs. This study evaluated the correlation of serum uric acid and proteinuria levels in...
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| Format: | Article |
| Language: | English |
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Universitas Padjadjaran
2015-03-01
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| Series: | Althea Medical Journal |
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| Online Access: | http://journal.fk.unpad.ac.id/index.php/amj/article/view/430 |
| _version_ | 1828431496310947840 |
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| author | Fatya Annisa Haryandini Tiene Rostini |
| author_facet | Fatya Annisa Haryandini Tiene Rostini |
| author_sort | Fatya Annisa Haryandini |
| collection | DOAJ |
| description | Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has diabetic nephropathy as a complication characterized by proteinuria. When type 2 diabetic patient’s kidney is damaged, hyperuricemia occurs. This study evaluated the correlation of serum uric acid and proteinuria levels in type 2 diabetic patients from outpatient Endocrine clinic at Dr. Hasan Sadikin General Hospital from January to December 2011.
Methods: In a cross-sectional study of 125 patients (55 male and 70 female) with type 2 diabetes mellitus, the data of serum uric acid, fasting plasma glucose, 2-h post oral glucose load plasma glucose, serum high-density lipoprotein cholesterol, serum trygliceride, and proteinuria levels were accessed from the medical record. Spearman test was used to calculate the correlation of serum uric acid and proteinuria levels. The research used secondary data taken from medical records of patients diagnosed with T2DM from outpatient Endocrine clinic of Department of Internal Medicine at Dr. Hasan Sadikin General Hospital Bandung who had a laboratory examination at Department of Clinical Pathology Dr. Hasan Sadikin General Hospital Bandung from January to December 2011.
Results: The mean age of the type 2 diabetic patients was 61.5±9.2 years old, with mean serum uric acid level of 6.2±1,8 mg/dl, of whom 52.8% had microalbuminuric and 4.8% had proteinuria. In type 2 diabetic patients, serum uric acid level correlated positively (r=0.273) with proteinuria (p=0.002).
Conclusions: Higher serum uric acid levels associated significantly positive with a greater probability of proteinuria in type 2 diabetic patients, indicating a potential marker for disease severity. |
| first_indexed | 2024-12-10T18:04:01Z |
| format | Article |
| id | doaj.art-553bdbe783fc4cb28d9fc795ac22413f |
| institution | Directory Open Access Journal |
| issn | 2337-4330 2337-4330 |
| language | English |
| last_indexed | 2024-12-10T18:04:01Z |
| publishDate | 2015-03-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | Althea Medical Journal |
| spelling | doaj.art-553bdbe783fc4cb28d9fc795ac22413f2022-12-22T01:38:41ZengUniversitas PadjadjaranAlthea Medical Journal2337-43302337-43302015-03-0121505310.15850/amj.v2n1.430Hyperuricemia and Proteinuria in Type 2 Diabetic PatientsFatya Annisa Haryandini0Tiene Rostini1Faculty of Medicine, Universitas PadjadjaranDepartment of Clinical Pathology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, BandungBackground: Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has diabetic nephropathy as a complication characterized by proteinuria. When type 2 diabetic patient’s kidney is damaged, hyperuricemia occurs. This study evaluated the correlation of serum uric acid and proteinuria levels in type 2 diabetic patients from outpatient Endocrine clinic at Dr. Hasan Sadikin General Hospital from January to December 2011. Methods: In a cross-sectional study of 125 patients (55 male and 70 female) with type 2 diabetes mellitus, the data of serum uric acid, fasting plasma glucose, 2-h post oral glucose load plasma glucose, serum high-density lipoprotein cholesterol, serum trygliceride, and proteinuria levels were accessed from the medical record. Spearman test was used to calculate the correlation of serum uric acid and proteinuria levels. The research used secondary data taken from medical records of patients diagnosed with T2DM from outpatient Endocrine clinic of Department of Internal Medicine at Dr. Hasan Sadikin General Hospital Bandung who had a laboratory examination at Department of Clinical Pathology Dr. Hasan Sadikin General Hospital Bandung from January to December 2011. Results: The mean age of the type 2 diabetic patients was 61.5±9.2 years old, with mean serum uric acid level of 6.2±1,8 mg/dl, of whom 52.8% had microalbuminuric and 4.8% had proteinuria. In type 2 diabetic patients, serum uric acid level correlated positively (r=0.273) with proteinuria (p=0.002). Conclusions: Higher serum uric acid levels associated significantly positive with a greater probability of proteinuria in type 2 diabetic patients, indicating a potential marker for disease severity.http://journal.fk.unpad.ac.id/index.php/amj/article/view/430Proteinuriatype 2 diabetes mellitusuric acid |
| spellingShingle | Fatya Annisa Haryandini Tiene Rostini Hyperuricemia and Proteinuria in Type 2 Diabetic Patients Althea Medical Journal Proteinuria type 2 diabetes mellitus uric acid |
| title | Hyperuricemia and Proteinuria in Type 2 Diabetic Patients |
| title_full | Hyperuricemia and Proteinuria in Type 2 Diabetic Patients |
| title_fullStr | Hyperuricemia and Proteinuria in Type 2 Diabetic Patients |
| title_full_unstemmed | Hyperuricemia and Proteinuria in Type 2 Diabetic Patients |
| title_short | Hyperuricemia and Proteinuria in Type 2 Diabetic Patients |
| title_sort | hyperuricemia and proteinuria in type 2 diabetic patients |
| topic | Proteinuria type 2 diabetes mellitus uric acid |
| url | http://journal.fk.unpad.ac.id/index.php/amj/article/view/430 |
| work_keys_str_mv | AT fatyaannisaharyandini hyperuricemiaandproteinuriaintype2diabeticpatients AT tienerostini hyperuricemiaandproteinuriaintype2diabeticpatients |