Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids

Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids

Abstract Mutations in N-glycanase 1 (NGLY1), which deglycosylates misfolded glycoproteins for degradation, can cause NGLY1 deficiency in patients and their abnormal fetal development in multiple organs, including microcephaly and other neurological disorders. Using cerebral organoids (COs) developed...

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Bibliographic Details
Main Authors: Victor J. T. Lin, Jiangnan Hu, Ashwini Zolekar, Max R. Salick, Parul Mittal, Jordan T. Bird, Peter Hoffmann, Ajamete Kaykas, Stephanie D. Byrum, Yu-Chieh Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04693-0

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