MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus
Alterations in lipid metabolism within beta cells and islets contributes to dysfunction and apoptosis of beta cells, leading to loss of insulin secretion and the onset of type 2 diabetes. Over the last decade, there has been an explosion of interest in understanding the landscape of gene expression...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/6/534 |
| _version_ | 1797530115602644992 |
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| author | Jamie M. R. Tarlton Steven Patterson Annette Graham |
| author_facet | Jamie M. R. Tarlton Steven Patterson Annette Graham |
| author_sort | Jamie M. R. Tarlton |
| collection | DOAJ |
| description | Alterations in lipid metabolism within beta cells and islets contributes to dysfunction and apoptosis of beta cells, leading to loss of insulin secretion and the onset of type 2 diabetes. Over the last decade, there has been an explosion of interest in understanding the landscape of gene expression which influences beta cell function, including the importance of small non-coding microRNA sequences in this context. This review sought to identify the microRNA sequences regulated by metabolic challenges in beta cells and islets, their targets, highlight their function and assess their possible relevance as biomarkers of disease progression in diabetic individuals. Predictive analysis was used to explore networks of genes targeted by these microRNA sequences, which may offer new therapeutic strategies to protect beta cell function and delay the onset of type 2 diabetes. |
| first_indexed | 2024-03-10T10:24:20Z |
| format | Article |
| id | doaj.art-553c4f6c6e804a64b32409d4a190a655 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T10:24:20Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-553c4f6c6e804a64b32409d4a190a6552023-11-22T00:08:58ZengMDPI AGBiology2079-77372021-06-0110653410.3390/biology10060534MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes MellitusJamie M. R. Tarlton0Steven Patterson1Annette Graham2Department of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UKDepartment of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UKDepartment of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UKAlterations in lipid metabolism within beta cells and islets contributes to dysfunction and apoptosis of beta cells, leading to loss of insulin secretion and the onset of type 2 diabetes. Over the last decade, there has been an explosion of interest in understanding the landscape of gene expression which influences beta cell function, including the importance of small non-coding microRNA sequences in this context. This review sought to identify the microRNA sequences regulated by metabolic challenges in beta cells and islets, their targets, highlight their function and assess their possible relevance as biomarkers of disease progression in diabetic individuals. Predictive analysis was used to explore networks of genes targeted by these microRNA sequences, which may offer new therapeutic strategies to protect beta cell function and delay the onset of type 2 diabetes.https://www.mdpi.com/2079-7737/10/6/534microRNAlipidlipotoxicityisletsbeta cells |
| spellingShingle | Jamie M. R. Tarlton Steven Patterson Annette Graham MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus Biology microRNA lipid lipotoxicity islets beta cells |
| title | MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus |
| title_full | MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus |
| title_fullStr | MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus |
| title_full_unstemmed | MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus |
| title_short | MicroRNA Sequences Modulated by Beta Cell Lipid Metabolism: Implications for Type 2 Diabetes Mellitus |
| title_sort | microrna sequences modulated by beta cell lipid metabolism implications for type 2 diabetes mellitus |
| topic | microRNA lipid lipotoxicity islets beta cells |
| url | https://www.mdpi.com/2079-7737/10/6/534 |
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