Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released from enteroendocrine L cells in response to meal ingestion. GLP-1 receptor agonists and GLP-1 enhancers have been clinically employed to treat diabetes owing to their glucose-dependent insulin-releasing activity. The release of G...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6623 |
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| author | Tohru Hira Aphichat Trakooncharoenvit Hayate Taguchi Hiroshi Hara |
| author_facet | Tohru Hira Aphichat Trakooncharoenvit Hayate Taguchi Hiroshi Hara |
| author_sort | Tohru Hira |
| collection | DOAJ |
| description | Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released from enteroendocrine L cells in response to meal ingestion. GLP-1 receptor agonists and GLP-1 enhancers have been clinically employed to treat diabetes owing to their glucose-dependent insulin-releasing activity. The release of GLP-1 is primarily stimulated by macronutrients such as glucose and fatty acids, which are nutritionally indispensable; however, excessive intake of sugar and fat is responsible for the development of obesity and diabetes. Therefore, GLP-1 releasing food factors, such as dietary peptides and non-nutrients, are deemed desirable for improving glucose tolerance. Human and animal studies have revealed that dietary proteins/peptides have a potent effect on stimulating GLP-1 secretion. Studies in enteroendocrine cell models have shown that dietary peptides, amino acids, and phytochemicals, such as quercetin, can directly stimulate GLP-1 secretion. In our animal experiments, these food factors improved glucose metabolism and increased GLP-1 secretion. Furthermore, some dietary peptides not only stimulated GLP-1 secretion but also reduced plasma peptidase activity, which is responsible for GLP-1 inactivation. Herein, we review the relationship between GLP-1 and food factors, especially dietary peptides and flavonoids. Accordingly, utilization of food factors with GLP-1-releasing/enhancing activity is a promising strategy for preventing and treating obesity and diabetes. |
| first_indexed | 2024-03-10T10:13:35Z |
| format | Article |
| id | doaj.art-553c972e4db14b6bb7b2e528d87d2bd1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:13:35Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-553c972e4db14b6bb7b2e528d87d2bd12023-11-22T01:01:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212662310.3390/ijms22126623Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing ActivityTohru Hira0Aphichat Trakooncharoenvit1Hayate Taguchi2Hiroshi Hara3Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, JapanGraduate School of Agriculture, Hokkaido University, Sapporo 060-8589, JapanSchool of Agriculture, Hokkaido University, Sapporo 060-8589, JapanDepartment of Food Science and Human Nutrition, Fuji Women’s University, Ishikari-shi 061-320, JapanGlucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released from enteroendocrine L cells in response to meal ingestion. GLP-1 receptor agonists and GLP-1 enhancers have been clinically employed to treat diabetes owing to their glucose-dependent insulin-releasing activity. The release of GLP-1 is primarily stimulated by macronutrients such as glucose and fatty acids, which are nutritionally indispensable; however, excessive intake of sugar and fat is responsible for the development of obesity and diabetes. Therefore, GLP-1 releasing food factors, such as dietary peptides and non-nutrients, are deemed desirable for improving glucose tolerance. Human and animal studies have revealed that dietary proteins/peptides have a potent effect on stimulating GLP-1 secretion. Studies in enteroendocrine cell models have shown that dietary peptides, amino acids, and phytochemicals, such as quercetin, can directly stimulate GLP-1 secretion. In our animal experiments, these food factors improved glucose metabolism and increased GLP-1 secretion. Furthermore, some dietary peptides not only stimulated GLP-1 secretion but also reduced plasma peptidase activity, which is responsible for GLP-1 inactivation. Herein, we review the relationship between GLP-1 and food factors, especially dietary peptides and flavonoids. Accordingly, utilization of food factors with GLP-1-releasing/enhancing activity is a promising strategy for preventing and treating obesity and diabetes.https://www.mdpi.com/1422-0067/22/12/6623GLP-1dietary peptidesflavonoids |
| spellingShingle | Tohru Hira Aphichat Trakooncharoenvit Hayate Taguchi Hiroshi Hara Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity International Journal of Molecular Sciences GLP-1 dietary peptides flavonoids |
| title | Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity |
| title_full | Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity |
| title_fullStr | Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity |
| title_full_unstemmed | Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity |
| title_short | Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity |
| title_sort | improvement of glucose tolerance by food factors having glucagon like peptide 1 releasing activity |
| topic | GLP-1 dietary peptides flavonoids |
| url | https://www.mdpi.com/1422-0067/22/12/6623 |
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