Thiohistidine Biosynthesis
Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification of thiohistidine biosyn...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2013-05-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/5396 |
| Summary: | Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification
of thiohistidine biosynthetic enzymes from Mycobacterium smegmatis and Erwinia tasmaniensis we investigate several aspects of sulfur-based redox biochemistry. For example, we are characterizing the catalytic mechanism of two thiohistidine biosynthetic enzymes which afford O2-dependent
sulfur insertion into the C(5)–H and C(2)–H bonds of the imidazolyl side chain of histidine.
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| ISSN: | 0009-4293 2673-2424 |