Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography
Abstract Purpose The aim of this study is to describe and compare the baseline demographic, ocular, and imaging characteristics of a cohort of patients with optic disc pit (ODP) or optic disc coloboma (ODC) maculopathy. Methods This retrospective study included patients diagnosed with ODP or ODC on...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | https://doi.org/10.1186/s40942-023-00484-7 |
| _version_ | 1827633470252253184 |
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| author | Vishma Prabhu Rubble Mangla Isha Acharya Ashit Handa Atul Thadani Yash Parmar Naresh Kumar Yadav Jay Chhablani Ramesh Venkatesh |
| author_facet | Vishma Prabhu Rubble Mangla Isha Acharya Ashit Handa Atul Thadani Yash Parmar Naresh Kumar Yadav Jay Chhablani Ramesh Venkatesh |
| author_sort | Vishma Prabhu |
| collection | DOAJ |
| description | Abstract Purpose The aim of this study is to describe and compare the baseline demographic, ocular, and imaging characteristics of a cohort of patients with optic disc pit (ODP) or optic disc coloboma (ODC) maculopathy. Methods This retrospective study included patients diagnosed with ODP or ODC on clinical examination between June 2017 and December 2022. These patients’ baseline demographics, ocular characteristics, and optical coherence tomography (OCT) imaging characteristics were analyzed. Results Fundus examination revealed 11 eyes of 11 patients with ODP and 14 eyes of 9 patients with ODC, respectively. On OCT, maculopathy was observed more frequently in ODP (n = 10) than in ODC (n = 4) [p = 0.004] cases. Eyes with ODP were more likely to exhibit retinoschisis and/or serous macular detachment [SMD] (n = 7, 70%), communication of the retinoschisis with the optic disc (p = 0.015), whereas the SMD did not communicate with the optic disc (p = 0.005), and significant outer retinal layer thinning (p = 0.015). In contrast, eyes with ODC exhibited only SMD (p = 0.005) and no retinoschisis on the non-colobomatous retina. SMD in ODC communicated with the margin of the optic disc. In both clinical entities, hyperreflective foci were observed in the SMD. Conclusion In summary, baseline maculopathy characteristics on OCT, including its type, location, and relationship to the optic disc, are among the most distinguishing characteristics between an ODP and an ODC. Trial Registration Number Not applicable. |
| first_indexed | 2024-03-09T15:00:33Z |
| format | Article |
| id | doaj.art-553f118c9c904e7aa49305e290e4cdd4 |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-03-09T15:00:33Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-553f118c9c904e7aa49305e290e4cdd42023-11-26T13:55:56ZengBMCInternational Journal of Retina and Vitreous2056-99202023-08-01911810.1186/s40942-023-00484-7Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomographyVishma Prabhu0Rubble Mangla1Isha Acharya2Ashit Handa3Atul Thadani4Yash Parmar5Naresh Kumar Yadav6Jay Chhablani7Ramesh Venkatesh8Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of MedicineDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousMedical Retina and Vitreoretinal Surgery, University of Pittsburgh School of MedicineDept. of Retina and VitreousAbstract Purpose The aim of this study is to describe and compare the baseline demographic, ocular, and imaging characteristics of a cohort of patients with optic disc pit (ODP) or optic disc coloboma (ODC) maculopathy. Methods This retrospective study included patients diagnosed with ODP or ODC on clinical examination between June 2017 and December 2022. These patients’ baseline demographics, ocular characteristics, and optical coherence tomography (OCT) imaging characteristics were analyzed. Results Fundus examination revealed 11 eyes of 11 patients with ODP and 14 eyes of 9 patients with ODC, respectively. On OCT, maculopathy was observed more frequently in ODP (n = 10) than in ODC (n = 4) [p = 0.004] cases. Eyes with ODP were more likely to exhibit retinoschisis and/or serous macular detachment [SMD] (n = 7, 70%), communication of the retinoschisis with the optic disc (p = 0.015), whereas the SMD did not communicate with the optic disc (p = 0.005), and significant outer retinal layer thinning (p = 0.015). In contrast, eyes with ODC exhibited only SMD (p = 0.005) and no retinoschisis on the non-colobomatous retina. SMD in ODC communicated with the margin of the optic disc. In both clinical entities, hyperreflective foci were observed in the SMD. Conclusion In summary, baseline maculopathy characteristics on OCT, including its type, location, and relationship to the optic disc, are among the most distinguishing characteristics between an ODP and an ODC. Trial Registration Number Not applicable.https://doi.org/10.1186/s40942-023-00484-7Optic disc pitOptic disc colobomaOptical coherence tomographyBaseline findings |
| spellingShingle | Vishma Prabhu Rubble Mangla Isha Acharya Ashit Handa Atul Thadani Yash Parmar Naresh Kumar Yadav Jay Chhablani Ramesh Venkatesh Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography International Journal of Retina and Vitreous Optic disc pit Optic disc coloboma Optical coherence tomography Baseline findings |
| title | Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography |
| title_full | Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography |
| title_fullStr | Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography |
| title_full_unstemmed | Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography |
| title_short | Evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography |
| title_sort | evaluation of baseline optic disc pit and optic disc coloboma maculopathy features by spectral domain optical coherence tomography |
| topic | Optic disc pit Optic disc coloboma Optical coherence tomography Baseline findings |
| url | https://doi.org/10.1186/s40942-023-00484-7 |
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