Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity
Nine sesquiterpenes, including eight pentalenenes (<b>1</b>–<b>8</b>) and one bolinane derivative (<b>9</b>), were isolated from the culture broth of a marine-derived actinobacterium <i>Streptomyces qinglanensis</i> 213DD-006. Among them, <b>1<...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/6/361 |
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| author | Cao Van Anh Jong Soon Kang Jeong-Wook Yang Joo-Hee Kwon Chang-Su Heo Hwa-Sun Lee Chan Hong Park Hee Jae Shin |
| author_facet | Cao Van Anh Jong Soon Kang Jeong-Wook Yang Joo-Hee Kwon Chang-Su Heo Hwa-Sun Lee Chan Hong Park Hee Jae Shin |
| author_sort | Cao Van Anh |
| collection | DOAJ |
| description | Nine sesquiterpenes, including eight pentalenenes (<b>1</b>–<b>8</b>) and one bolinane derivative (<b>9</b>), were isolated from the culture broth of a marine-derived actinobacterium <i>Streptomyces qinglanensis</i> 213DD-006. Among them, <b>1</b>, <b>4</b>, <b>7</b>, and <b>9</b> were new compounds. Their planar structures were determined by spectroscopic methods (HRMS, 1D, and 2D NMR), and the absolute configuration was established by biosynthesis consideration and electronic-circular-dichroism (ECD) calculations. All the isolated compounds were screened for their cytotoxicity against six solid and seven blood cancer cell lines. Compounds <b>4</b>–<b>6</b> and <b>8</b> showed a moderate activity against all of the tested solid cell lines, with GI<sub>50</sub> values ranging from 1.97 to 3.46 µM. |
| first_indexed | 2024-03-11T02:13:23Z |
| format | Article |
| id | doaj.art-554390018def442e91fbcca969990162 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T02:13:23Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-554390018def442e91fbcca9699901622023-11-18T11:22:49ZengMDPI AGMarine Drugs1660-33972023-06-0121636110.3390/md21060361Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic ActivityCao Van Anh0Jong Soon Kang1Jeong-Wook Yang2Joo-Hee Kwon3Chang-Su Heo4Hwa-Sun Lee5Chan Hong Park6Hee Jae Shin7Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Republic of KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Republic of KoreaLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Republic of KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of KoreaDokdo Research Center, Korea Institute of Ocean Science and Technology, 48 Haeyanggwahak-gil, Jukbyeon-myeon, Uljin-gun 767-813, Gyeongsangbuk-do, Republic of KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of KoreaNine sesquiterpenes, including eight pentalenenes (<b>1</b>–<b>8</b>) and one bolinane derivative (<b>9</b>), were isolated from the culture broth of a marine-derived actinobacterium <i>Streptomyces qinglanensis</i> 213DD-006. Among them, <b>1</b>, <b>4</b>, <b>7</b>, and <b>9</b> were new compounds. Their planar structures were determined by spectroscopic methods (HRMS, 1D, and 2D NMR), and the absolute configuration was established by biosynthesis consideration and electronic-circular-dichroism (ECD) calculations. All the isolated compounds were screened for their cytotoxicity against six solid and seven blood cancer cell lines. Compounds <b>4</b>–<b>6</b> and <b>8</b> showed a moderate activity against all of the tested solid cell lines, with GI<sub>50</sub> values ranging from 1.97 to 3.46 µM.https://www.mdpi.com/1660-3397/21/6/361<i>Streptomyces</i> sp.sesquiterpenespentalenenebolinanecytotoxicity |
| spellingShingle | Cao Van Anh Jong Soon Kang Jeong-Wook Yang Joo-Hee Kwon Chang-Su Heo Hwa-Sun Lee Chan Hong Park Hee Jae Shin Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity Marine Drugs <i>Streptomyces</i> sp. sesquiterpenes pentalenene bolinane cytotoxicity |
| title | Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity |
| title_full | Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity |
| title_fullStr | Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity |
| title_full_unstemmed | Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity |
| title_short | Sesquiterpenes from <i>Streptomyces qinglanensis</i> and Their Cytotoxic Activity |
| title_sort | sesquiterpenes from i streptomyces qinglanensis i and their cytotoxic activity |
| topic | <i>Streptomyces</i> sp. sesquiterpenes pentalenene bolinane cytotoxicity |
| url | https://www.mdpi.com/1660-3397/21/6/361 |
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