Golgi-Targeting Anticancer Natural Products
The Golgi apparatus plays an important role in maintaining cell homeostasis by serving as a biosynthetic center for glycans, lipids and post-translationally modified proteins and as a sorting center for vesicular transport of proteins to specific destinations. Moreover, it provides a signaling hub t...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/7/2086 |
| _version_ | 1797608243546030080 |
|---|---|
| author | Myat Nyein Khine Kaori Sakurai |
| author_facet | Myat Nyein Khine Kaori Sakurai |
| author_sort | Myat Nyein Khine |
| collection | DOAJ |
| description | The Golgi apparatus plays an important role in maintaining cell homeostasis by serving as a biosynthetic center for glycans, lipids and post-translationally modified proteins and as a sorting center for vesicular transport of proteins to specific destinations. Moreover, it provides a signaling hub that facilitates not only membrane trafficking processes but also cellular response pathways to various types of stresses. Altered signaling at the Golgi apparatus has emerged as a key regulator of tumor growth and survival. Among the small molecules that can specifically perturb or modulate Golgi proteins and organization, natural products with anticancer property have been identified as powerful chemical probes in deciphering Golgi-related pathways and, in particular, recently described Golgi stress response pathways. In this review, we highlight a set of Golgi-targeting natural products that enabled the characterization of the Golgi-mediated signaling events leading to cancer cell death and discuss the potential for selectively exploiting these pathways for the development of novel chemotherapeutic agents. |
| first_indexed | 2024-03-11T05:40:43Z |
| format | Article |
| id | doaj.art-5543c7260a0d45189ba7b4389086b21b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:40:43Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5543c7260a0d45189ba7b4389086b21b2023-11-17T16:25:55ZengMDPI AGCancers2072-66942023-03-01157208610.3390/cancers15072086Golgi-Targeting Anticancer Natural ProductsMyat Nyein Khine0Kaori Sakurai1Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, JapanDepartment of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, JapanThe Golgi apparatus plays an important role in maintaining cell homeostasis by serving as a biosynthetic center for glycans, lipids and post-translationally modified proteins and as a sorting center for vesicular transport of proteins to specific destinations. Moreover, it provides a signaling hub that facilitates not only membrane trafficking processes but also cellular response pathways to various types of stresses. Altered signaling at the Golgi apparatus has emerged as a key regulator of tumor growth and survival. Among the small molecules that can specifically perturb or modulate Golgi proteins and organization, natural products with anticancer property have been identified as powerful chemical probes in deciphering Golgi-related pathways and, in particular, recently described Golgi stress response pathways. In this review, we highlight a set of Golgi-targeting natural products that enabled the characterization of the Golgi-mediated signaling events leading to cancer cell death and discuss the potential for selectively exploiting these pathways for the development of novel chemotherapeutic agents.https://www.mdpi.com/2072-6694/15/7/2086natural productsanticancer agentsGolgi apparatusstress responsecancer signaling |
| spellingShingle | Myat Nyein Khine Kaori Sakurai Golgi-Targeting Anticancer Natural Products Cancers natural products anticancer agents Golgi apparatus stress response cancer signaling |
| title | Golgi-Targeting Anticancer Natural Products |
| title_full | Golgi-Targeting Anticancer Natural Products |
| title_fullStr | Golgi-Targeting Anticancer Natural Products |
| title_full_unstemmed | Golgi-Targeting Anticancer Natural Products |
| title_short | Golgi-Targeting Anticancer Natural Products |
| title_sort | golgi targeting anticancer natural products |
| topic | natural products anticancer agents Golgi apparatus stress response cancer signaling |
| url | https://www.mdpi.com/2072-6694/15/7/2086 |
| work_keys_str_mv | AT myatnyeinkhine golgitargetinganticancernaturalproducts AT kaorisakurai golgitargetinganticancernaturalproducts |