Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma
Introduction: Primary lung papillary neoplasms are very rare and less than 30 cases of papillary adenomas have been described. Lung-derived papillary lesions arising in ovarian mature cystic teratoma are extremely rare and, to the best of the authors’ knowledge, only one case has been reported. Here...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5340 |
| _version_ | 1828215126501621760 |
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| author | S. Lane A. Newman M. Vergine K. Allan F. Usifo C.C. Yeoh S. Rahimi |
| author_facet | S. Lane A. Newman M. Vergine K. Allan F. Usifo C.C. Yeoh S. Rahimi |
| author_sort | S. Lane |
| collection | DOAJ |
| description | Introduction: Primary lung papillary neoplasms are very rare and less than 30 cases of papillary adenomas have been described. Lung-derived papillary lesions arising in ovarian mature cystic teratoma are extremely rare and, to the best of the authors’ knowledge, only one case has been reported. Herein they report the second case and discuss the differential diagnoses. Case Report: A 32-year-old woman presented with bilateral ovarian mature cystic teratoma (MCT) (“dermoid”). The right side teratoma, very close to the thyroid tissue (struma ovarii), presented a morphologically benign mass, with complex papillary structures and psammoma bodies, which mimicked a thyroid papillary carcinoma (TPC). Immunohistochemistry showed diffuse positive staining with EMA, cytokeratins, and patchy positive staining with TTF1 and surfactant apoprotein A. Thyroglobulin, PAX-8, HMBE1, chromogranin, synaptophysin, CD56, CEA, p63, and BRAF were negative. The work-up for metastasis was negative. Close clinical and instrumental follow-up was decided following consultation with the lung and gynaecological multidisciplinary team. Conclusion: This is the second case of benign appearing, lung-derived papillary neoplasm arising in an ovarian MCT. In view of the clinical context, histological criteria used in lung pathology cannot be applied with confidence in this case. The most appropriate term would be pulmonary-derived papillary adenomatoid proliferation. This novel entity will be useful for pathologists and clinicians in diagnosing and differentiating this very rare disease from other lesions arising in ovarian teratomas. |
| first_indexed | 2024-04-12T15:16:15Z |
| format | Article |
| id | doaj.art-5544566e11c848fa886c6d772ad8a7e0 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-12T15:16:15Z |
| publishDate | 2020-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-5544566e11c848fa886c6d772ad8a7e02022-12-22T03:27:37ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-08-0147461161310.31083/j.ceog.2020.04.5340S0390-6663(20)00330-9Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratomaS. Lane0A. Newman1M. Vergine2K. Allan3F. Usifo4C.C. Yeoh5S. Rahimi6Frontier Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United KingdomFrontier Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United KingdomFrontier Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United KingdomFrontier Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United KingdomGynaecology Department, Brighton and Sussex University Hospitals NHS Trust, Brighton, United KingdomDepartment of Oncology, Queen Alexandra Hospital, Portsmouth, United KingdomFrontier Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United KingdomIntroduction: Primary lung papillary neoplasms are very rare and less than 30 cases of papillary adenomas have been described. Lung-derived papillary lesions arising in ovarian mature cystic teratoma are extremely rare and, to the best of the authors’ knowledge, only one case has been reported. Herein they report the second case and discuss the differential diagnoses. Case Report: A 32-year-old woman presented with bilateral ovarian mature cystic teratoma (MCT) (“dermoid”). The right side teratoma, very close to the thyroid tissue (struma ovarii), presented a morphologically benign mass, with complex papillary structures and psammoma bodies, which mimicked a thyroid papillary carcinoma (TPC). Immunohistochemistry showed diffuse positive staining with EMA, cytokeratins, and patchy positive staining with TTF1 and surfactant apoprotein A. Thyroglobulin, PAX-8, HMBE1, chromogranin, synaptophysin, CD56, CEA, p63, and BRAF were negative. The work-up for metastasis was negative. Close clinical and instrumental follow-up was decided following consultation with the lung and gynaecological multidisciplinary team. Conclusion: This is the second case of benign appearing, lung-derived papillary neoplasm arising in an ovarian MCT. In view of the clinical context, histological criteria used in lung pathology cannot be applied with confidence in this case. The most appropriate term would be pulmonary-derived papillary adenomatoid proliferation. This novel entity will be useful for pathologists and clinicians in diagnosing and differentiating this very rare disease from other lesions arising in ovarian teratomas.https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5340lungovaryteratomapapillaryadenoma |
| spellingShingle | S. Lane A. Newman M. Vergine K. Allan F. Usifo C.C. Yeoh S. Rahimi Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma Clinical and Experimental Obstetrics & Gynecology lung ovary teratoma papillary adenoma |
| title | Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma |
| title_full | Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma |
| title_fullStr | Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma |
| title_full_unstemmed | Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma |
| title_short | Pulmonary-derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma |
| title_sort | pulmonary derived papillary adenomatoid proliferation arising in ovarian mature cystic teratoma |
| topic | lung ovary teratoma papillary adenoma |
| url | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5340 |
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