How Long to Continue Eyelid Hygiene to Treat Meibomian Gland Dysfunction
To determine the efficacy duration of eyelid hygiene for meibomian gland dysfunction (MGD) treatment, a total of 1015 participants with primary MGD, followed for at least 6 months, were enrolled. The participants were classified into the eyelid hygiene group and the control group. The participants w...
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/529 |
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| author | Hyunmin Ahn Bo Yi Kim Jinyoung Kim Yong Woo Ji Ikhyun Jun Tae-im Kim Hyung Keun Lee Kyoung Yul Seo |
| author_facet | Hyunmin Ahn Bo Yi Kim Jinyoung Kim Yong Woo Ji Ikhyun Jun Tae-im Kim Hyung Keun Lee Kyoung Yul Seo |
| author_sort | Hyunmin Ahn |
| collection | DOAJ |
| description | To determine the efficacy duration of eyelid hygiene for meibomian gland dysfunction (MGD) treatment, a total of 1015 participants with primary MGD, followed for at least 6 months, were enrolled. The participants were classified into the eyelid hygiene group and the control group. The participants who had stopped eyelid hygiene at any point in the observation period after the initial 2 months were classified into the withdrawal group. Analysis was conducted with a generalized linear mixed model. Treatment group, age, sex, ocular surface inflammation, anti-inflammatory treatments, and baseline MGD subtype were considered as fixed effects, and the individual factor was considered as a random effect. The MGD stage decreased significantly for the observational period in the eyelid hygiene group (<i>p</i> < 0.001). Approximately 40.1% of the participants continuously maintained eyelid hygiene throughout the observational period. The MGD stage in the eyelid hygiene group continued to decrease for 6 months and was maintained thereafter. After 4 months of stopping eyelid hygiene, the MGD stage in the withdrawal group was worse than in the eyelid hygiene group (<i>p</i> < 0.001) and similar to that in the control group (<i>p</i> = 0.762). Maintaining eyelid hygiene was significantly effective in MGD treatment. Efficacy increased with treatment for 6 months, and the efficacy duration was maintained for 4 months even after stopping eyelid hygiene. Therefore, we recommend that patients with MGD maintain eyelid hygiene, and compliance should be checked continuously. |
| first_indexed | 2024-03-09T23:41:46Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:41:46Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5544dee9e4064e9991481d6490af34722023-11-23T16:49:54ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111352910.3390/jcm11030529How Long to Continue Eyelid Hygiene to Treat Meibomian Gland DysfunctionHyunmin Ahn0Bo Yi Kim1Jinyoung Kim2Yong Woo Ji3Ikhyun Jun4Tae-im Kim5Hyung Keun Lee6Kyoung Yul Seo7Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Medicine, Armed Forces Daegu Hospital, Daegu 38427, KoreaDepartment of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaTo determine the efficacy duration of eyelid hygiene for meibomian gland dysfunction (MGD) treatment, a total of 1015 participants with primary MGD, followed for at least 6 months, were enrolled. The participants were classified into the eyelid hygiene group and the control group. The participants who had stopped eyelid hygiene at any point in the observation period after the initial 2 months were classified into the withdrawal group. Analysis was conducted with a generalized linear mixed model. Treatment group, age, sex, ocular surface inflammation, anti-inflammatory treatments, and baseline MGD subtype were considered as fixed effects, and the individual factor was considered as a random effect. The MGD stage decreased significantly for the observational period in the eyelid hygiene group (<i>p</i> < 0.001). Approximately 40.1% of the participants continuously maintained eyelid hygiene throughout the observational period. The MGD stage in the eyelid hygiene group continued to decrease for 6 months and was maintained thereafter. After 4 months of stopping eyelid hygiene, the MGD stage in the withdrawal group was worse than in the eyelid hygiene group (<i>p</i> < 0.001) and similar to that in the control group (<i>p</i> = 0.762). Maintaining eyelid hygiene was significantly effective in MGD treatment. Efficacy increased with treatment for 6 months, and the efficacy duration was maintained for 4 months even after stopping eyelid hygiene. Therefore, we recommend that patients with MGD maintain eyelid hygiene, and compliance should be checked continuously.https://www.mdpi.com/2077-0383/11/3/529complianceeyelid hygienemeibomian gland dysfunction |
| spellingShingle | Hyunmin Ahn Bo Yi Kim Jinyoung Kim Yong Woo Ji Ikhyun Jun Tae-im Kim Hyung Keun Lee Kyoung Yul Seo How Long to Continue Eyelid Hygiene to Treat Meibomian Gland Dysfunction Journal of Clinical Medicine compliance eyelid hygiene meibomian gland dysfunction |
| title | How Long to Continue Eyelid Hygiene to Treat Meibomian Gland Dysfunction |
| title_full | How Long to Continue Eyelid Hygiene to Treat Meibomian Gland Dysfunction |
| title_fullStr | How Long to Continue Eyelid Hygiene to Treat Meibomian Gland Dysfunction |
| title_full_unstemmed | How Long to Continue Eyelid Hygiene to Treat Meibomian Gland Dysfunction |
| title_short | How Long to Continue Eyelid Hygiene to Treat Meibomian Gland Dysfunction |
| title_sort | how long to continue eyelid hygiene to treat meibomian gland dysfunction |
| topic | compliance eyelid hygiene meibomian gland dysfunction |
| url | https://www.mdpi.com/2077-0383/11/3/529 |
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