Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons
There is limited research on the association between longitudinal variability in serum uric acid (SUA) and all-cause mortality in the general population, although recent studies have suggested that changes in SUA are associated with all-cause mortality in adults. This study aims to examine the assoc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2023/7382320 |
| _version_ | 1811154458996899840 |
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| author | Ryuichi Kawamoto Asuka Kikuchi Daisuke Ninomiya Teru Kumagi |
| author_facet | Ryuichi Kawamoto Asuka Kikuchi Daisuke Ninomiya Teru Kumagi |
| author_sort | Ryuichi Kawamoto |
| collection | DOAJ |
| description | There is limited research on the association between longitudinal variability in serum uric acid (SUA) and all-cause mortality in the general population, although recent studies have suggested that changes in SUA are associated with all-cause mortality in adults. This study aims to examine the association between percentage change in SUA (%dSUA = 100 × (cohort 2 SUA − cohort 1 SUA)/(time × cohort 1 SUA) and all-cause mortality. This study is based on 1,301 participants, of whom 543 were male (63 ± 11 years) and 758 were female (63 ± 9 years). We obtained adjusted relative risk estimates for all-cause mortality and used a Cox proportional hazards model, adjusted for possible confounders, to determine the hazard ratio (HR) and 95% confidence interval (CI) of %dSUA. Of all the participants, 79 (6.1%) were deceased, and of these, 45 were male (8.3%) and 34 were female (4.5%). The multivariable-adjusted HRs (95% CI) for all-cause mortality for the first, second to fourth (reference), and fifth %dSUA quintiles were 3.79 (1.67–8.48), 1.00, and 0.87 (0.29–2.61) for male participants and 4.00 (1.43–11.2), 1.00, and 1.19 (0.46–3.05) for female participants, respectively. Participants with a body mass index of <22 kg/m2 had a significantly higher HR, forming a U-shaped curve for the first (HR, 7.59; 95% CI, 2.13–27.0) and fifth quintiles (HR, 2.93; 95% CI, 1.05–8.18) relative to the reference. Percentage change in SUA is independently and significantly associated with future all-cause mortality among community-dwelling persons. |
| first_indexed | 2024-04-10T04:15:58Z |
| format | Article |
| id | doaj.art-554732d3501c4019bdfc1ced32c5e0e9 |
| institution | Directory Open Access Journal |
| issn | 1687-8779 |
| language | English |
| last_indexed | 2024-04-10T04:15:58Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj.art-554732d3501c4019bdfc1ced32c5e0e92023-03-12T00:00:15ZengHindawi LimitedInternational Journal of Analytical Chemistry1687-87792023-01-01202310.1155/2023/7382320Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling PersonsRyuichi Kawamoto0Asuka Kikuchi1Daisuke Ninomiya2Teru Kumagi3Department of Community MedicineDepartment of Community MedicineDepartment of Community MedicineDepartment of Community MedicineThere is limited research on the association between longitudinal variability in serum uric acid (SUA) and all-cause mortality in the general population, although recent studies have suggested that changes in SUA are associated with all-cause mortality in adults. This study aims to examine the association between percentage change in SUA (%dSUA = 100 × (cohort 2 SUA − cohort 1 SUA)/(time × cohort 1 SUA) and all-cause mortality. This study is based on 1,301 participants, of whom 543 were male (63 ± 11 years) and 758 were female (63 ± 9 years). We obtained adjusted relative risk estimates for all-cause mortality and used a Cox proportional hazards model, adjusted for possible confounders, to determine the hazard ratio (HR) and 95% confidence interval (CI) of %dSUA. Of all the participants, 79 (6.1%) were deceased, and of these, 45 were male (8.3%) and 34 were female (4.5%). The multivariable-adjusted HRs (95% CI) for all-cause mortality for the first, second to fourth (reference), and fifth %dSUA quintiles were 3.79 (1.67–8.48), 1.00, and 0.87 (0.29–2.61) for male participants and 4.00 (1.43–11.2), 1.00, and 1.19 (0.46–3.05) for female participants, respectively. Participants with a body mass index of <22 kg/m2 had a significantly higher HR, forming a U-shaped curve for the first (HR, 7.59; 95% CI, 2.13–27.0) and fifth quintiles (HR, 2.93; 95% CI, 1.05–8.18) relative to the reference. Percentage change in SUA is independently and significantly associated with future all-cause mortality among community-dwelling persons.http://dx.doi.org/10.1155/2023/7382320 |
| spellingShingle | Ryuichi Kawamoto Asuka Kikuchi Daisuke Ninomiya Teru Kumagi Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons International Journal of Analytical Chemistry |
| title | Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons |
| title_full | Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons |
| title_fullStr | Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons |
| title_full_unstemmed | Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons |
| title_short | Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons |
| title_sort | change in serum uric acid is a useful predictor of all cause mortality among community dwelling persons |
| url | http://dx.doi.org/10.1155/2023/7382320 |
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