Activation of Neutrophil Granulocytes by Platelet-Activating Factor Is Impaired During Experimental Sepsis

Activation of Neutrophil Granulocytes by Platelet-Activating Factor Is Impaired During Experimental Sepsis

Platelet-activating factor (PAF) is an important mediator of the systemic inflammatory response. In the case of sepsis, proper activation and function of neutrophils as the first line of cellular defense are based on a well-balanced physiological response. However, little is known about the role of...

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Bibliographic Details
Main Authors: Stefan Hug, Stefan Bernhard, Alexander Elias Paul Stratmann, Maike Erber, Lisa Wohlgemuth, Christiane Leonie Knapp, Jonas Martin Bauer, Laura Vidoni, Michael Fauler, Karl Josef Föhr, Peter Radermacher, Andrea Hoffmann, Markus Huber-Lang, David Alexander Christian Messerer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
platelet-activating factor
neutrophil granulocytes
intracellular pH
sepsis
membrane potential
flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642867/full

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