Impaired Functional Connectivity Underlies Fragile X Syndrome

Impaired Functional Connectivity Underlies Fragile X Syndrome

Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is caused by a developmentally regulated silencing of the <i>FMR1</i> gene, but its effect on human neuronal network development and function is not fully understood. Here, we isolated isogenic human emb...

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Bibliographic Details
Main Authors: Lital Gildin, Rossana Rauti, Ofir Vardi, Liron Kuznitsov-Yanovsky, Ben M. Maoz, Menahem Segal, Dalit Ben-Yosef
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
Fragile X syndrome
disease modeling
human embryonic stem cells
neural differentiation
MEA
electrophysiology
Online Access:https://www.mdpi.com/1422-0067/23/4/2048

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