Expression Of Cyclooxygenase-2 And Interlukin-6 Mrnas In Iraqi Patients With Breast Cancer
Background: Breast cancer is one of the most common malignant tumors that endanger women's health internationally, relatively uncommon in men, accounting for only 1% of all cancer cases. Location, way of life, age at marriage, and obesity are a few environmental variables that increase the ris...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine, University of Kufa
2023-12-01
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| Series: | مجلة الكوفة الطبية |
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| Online Access: | https://journal.uokufa.edu.iq/index.php/kmj/article/view/13259 |
| Summary: | Background: Breast cancer is one of the most common malignant tumors that endanger women's health internationally, relatively uncommon in men, accounting for only 1% of all cancer cases. Location, way of life, age at marriage, and obesity are a few environmental variables that increase the risk of breast cancer.
Aim of study: the study aims to explain how the pro-inflammatory cytokines (IL-6) induce the inflammatory events in patients with breast cancer and to describe whether cyclooxygenase-2 promotes tumor growth in breast cancer or not.
Materials and methods: The current case-control cross-sectional study included 45 patients with a history of breast cancer, and it was done in multiple places in Hilla, Babylon Province, between November 2022 and March 2023.Interlukin-6 and Cyclooxygenase-2 by QPCR.
Results: The results have shown a significant increase of IL-6 (P < 0.05) in patients compared with control. Also, the results have shown a significant increase (P < 0.05) of COX2 in patients compared with control.
Conclusion: There is a significant increase in the means of Interlukin-6 and Cyclooxygenase-2 in the patients with breast cancer.
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| ISSN: | 1993-517X 2709-4464 |