Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients
Bipolar disorder (BD) is a chronic mental disorder that affects more than 1% of the population worldwide. Over 65% of patients experience early onset of the disease. Most cases of juvenile bipolar disorder begin with a depressed mood episode, and up to 50% of youth initially diagnosed with major dep...
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/18/4064 |
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| author | Maria Skibinska Pawel Kapelski Monika Dmitrzak-Weglarz Natalia Lepczynska Joanna Pawlak Joanna Twarowska-Hauser Aleksandra Szczepankiewicz Aleksandra Rajewska-Rager |
| author_facet | Maria Skibinska Pawel Kapelski Monika Dmitrzak-Weglarz Natalia Lepczynska Joanna Pawlak Joanna Twarowska-Hauser Aleksandra Szczepankiewicz Aleksandra Rajewska-Rager |
| author_sort | Maria Skibinska |
| collection | DOAJ |
| description | Bipolar disorder (BD) is a chronic mental disorder that affects more than 1% of the population worldwide. Over 65% of patients experience early onset of the disease. Most cases of juvenile bipolar disorder begin with a depressed mood episode, and up to 50% of youth initially diagnosed with major depression go onto developing a BD. Our study aimed to find biomarkers of diagnosis conversion in young patients with mood disorders. We performed a two-year follow-up study on 79 adolescent patients diagnosed with MDD or BD, with a detailed clinical assessment at five visits. We monitored diagnosis change from MDD to BD. The control group consisted of 31 healthy youths. According to the neurodevelopmental and neuroimmunological hypotheses of mood disorders, we analyzed serum levels of brain-derived neurotrophic factor (BDNF), proBDNF, epidermal growth factor (EGF), migration inhibitory factor (MIF), stem cell factor (SCF), and correlations with clinical factors. We detected a significant disease-dependent increase in EGF level in MDD and BP patients at baseline exacerbation of depressive or hypomanic/manic episodes as well as in euthymic state compared to healthy controls. No potential biological predictors of disease conversion were found. Replication studies on a larger cohort of patients are needed. |
| first_indexed | 2024-03-10T07:33:47Z |
| format | Article |
| id | doaj.art-555271a3834944d6946bdf9feb2d02b2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T07:33:47Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-555271a3834944d6946bdf9feb2d02b22023-11-22T13:38:55ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011018406410.3390/jcm10184064Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult PatientsMaria Skibinska0Pawel Kapelski1Monika Dmitrzak-Weglarz2Natalia Lepczynska3Joanna Pawlak4Joanna Twarowska-Hauser5Aleksandra Szczepankiewicz6Aleksandra Rajewska-Rager7Department of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Child and Adolescent Psychiatry, Karol Jonscher Clinical Hospital, Poznan University of Medical Sciences, Szpitalna 27/33 St., 60-572 Poznan, PolandDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, PolandLaboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Szpitalna 27/33 St., 60-572 Poznan, PolandDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, PolandBipolar disorder (BD) is a chronic mental disorder that affects more than 1% of the population worldwide. Over 65% of patients experience early onset of the disease. Most cases of juvenile bipolar disorder begin with a depressed mood episode, and up to 50% of youth initially diagnosed with major depression go onto developing a BD. Our study aimed to find biomarkers of diagnosis conversion in young patients with mood disorders. We performed a two-year follow-up study on 79 adolescent patients diagnosed with MDD or BD, with a detailed clinical assessment at five visits. We monitored diagnosis change from MDD to BD. The control group consisted of 31 healthy youths. According to the neurodevelopmental and neuroimmunological hypotheses of mood disorders, we analyzed serum levels of brain-derived neurotrophic factor (BDNF), proBDNF, epidermal growth factor (EGF), migration inhibitory factor (MIF), stem cell factor (SCF), and correlations with clinical factors. We detected a significant disease-dependent increase in EGF level in MDD and BP patients at baseline exacerbation of depressive or hypomanic/manic episodes as well as in euthymic state compared to healthy controls. No potential biological predictors of disease conversion were found. Replication studies on a larger cohort of patients are needed.https://www.mdpi.com/2077-0383/10/18/4064adolescent mood disordersmajor depressive disorder (MDD)bipolar disorder (BD)brain-derived neurotrophic factor (BDNF)epidermal growth factor (EGF)migration inhibitory factor (MIF) |
| spellingShingle | Maria Skibinska Pawel Kapelski Monika Dmitrzak-Weglarz Natalia Lepczynska Joanna Pawlak Joanna Twarowska-Hauser Aleksandra Szczepankiewicz Aleksandra Rajewska-Rager Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients Journal of Clinical Medicine adolescent mood disorders major depressive disorder (MDD) bipolar disorder (BD) brain-derived neurotrophic factor (BDNF) epidermal growth factor (EGF) migration inhibitory factor (MIF) |
| title | Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients |
| title_full | Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients |
| title_fullStr | Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients |
| title_full_unstemmed | Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients |
| title_short | Elevated Epidermal Growth Factor (EGF) as Candidate Biomarker of Mood Disorders—Longitudinal Study in Adolescent and Young Adult Patients |
| title_sort | elevated epidermal growth factor egf as candidate biomarker of mood disorders longitudinal study in adolescent and young adult patients |
| topic | adolescent mood disorders major depressive disorder (MDD) bipolar disorder (BD) brain-derived neurotrophic factor (BDNF) epidermal growth factor (EGF) migration inhibitory factor (MIF) |
| url | https://www.mdpi.com/2077-0383/10/18/4064 |
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