Small Vessel Disease
Small vessel disease (SVD) refers to conditions where damage to arterioles and capillaries is predominant, leading to reduced, or interrupted perfusion of the affected organ. Data suggest that when this condition is evident in any organ, it is already systemic in its occurrence and consequences. SVD...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01020/full |
| _version_ | 1819088439521312768 |
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| author | Antoine M. Hakim Antoine M. Hakim Antoine M. Hakim |
| author_facet | Antoine M. Hakim Antoine M. Hakim Antoine M. Hakim |
| author_sort | Antoine M. Hakim |
| collection | DOAJ |
| description | Small vessel disease (SVD) refers to conditions where damage to arterioles and capillaries is predominant, leading to reduced, or interrupted perfusion of the affected organ. Data suggest that when this condition is evident in any organ, it is already systemic in its occurrence and consequences. SVD affects primarily organs that receive significant portions of cardiac output such as the brain, the kidney, and the retina. Thus, SVD is a major etiologic cause in debilitating conditions such as renal failure, blindness, lacunar infarcts, and dementia. The factors that lead to this devastating condition include all the known vascular risk factors when they are not strictly controlled, but lifestyles that include sedentary existence, obesity, and poor sleep patterns are also recognized drivers of SVD. In addition, depression is now recognized as a vascular risk factor. Inflammation is a mediator of SVD, but it is not known which factor(s) predominate in its etiology. This article emphasizes the need for more investigations to define this link further and suggests clinical and societal responses that might reduce the major impacts of this condition on populations. |
| first_indexed | 2024-12-21T21:52:04Z |
| format | Article |
| id | doaj.art-5553180d16534ba485aebeaf562dc33d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T21:52:04Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-5553180d16534ba485aebeaf562dc33d2022-12-21T18:49:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-09-011010.3389/fneur.2019.01020453063Small Vessel DiseaseAntoine M. Hakim0Antoine M. Hakim1Antoine M. Hakim2Ottawa Hospital Research Institute, Ottawa, ON, CanadaFaculty of Medicine, Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, CanadaDivision of Neurology, University of Ottawa, Ottawa, ON, CanadaSmall vessel disease (SVD) refers to conditions where damage to arterioles and capillaries is predominant, leading to reduced, or interrupted perfusion of the affected organ. Data suggest that when this condition is evident in any organ, it is already systemic in its occurrence and consequences. SVD affects primarily organs that receive significant portions of cardiac output such as the brain, the kidney, and the retina. Thus, SVD is a major etiologic cause in debilitating conditions such as renal failure, blindness, lacunar infarcts, and dementia. The factors that lead to this devastating condition include all the known vascular risk factors when they are not strictly controlled, but lifestyles that include sedentary existence, obesity, and poor sleep patterns are also recognized drivers of SVD. In addition, depression is now recognized as a vascular risk factor. Inflammation is a mediator of SVD, but it is not known which factor(s) predominate in its etiology. This article emphasizes the need for more investigations to define this link further and suggests clinical and societal responses that might reduce the major impacts of this condition on populations.https://www.frontiersin.org/article/10.3389/fneur.2019.01020/fullSVDvascular risk factorsinflammationdementialifestyle |
| spellingShingle | Antoine M. Hakim Antoine M. Hakim Antoine M. Hakim Small Vessel Disease Frontiers in Neurology SVD vascular risk factors inflammation dementia lifestyle |
| title | Small Vessel Disease |
| title_full | Small Vessel Disease |
| title_fullStr | Small Vessel Disease |
| title_full_unstemmed | Small Vessel Disease |
| title_short | Small Vessel Disease |
| title_sort | small vessel disease |
| topic | SVD vascular risk factors inflammation dementia lifestyle |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.01020/full |
| work_keys_str_mv | AT antoinemhakim smallvesseldisease AT antoinemhakim smallvesseldisease AT antoinemhakim smallvesseldisease |