Metabolic flexibility during sleep
Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-97301-8 |
| _version_ | 1818344710278742016 |
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| author | Simeng Zhang Yoshiaki Tanaka Asuka Ishihara Akiko Uchizawa Insung Park Kaito Iwayama Hitomi Ogata Katsuhiko Yajima Naomi Omi Makoto Satoh Masashi Yanagisawa Hiroyuki Sagayama Kumpei Tokuyama |
| author_facet | Simeng Zhang Yoshiaki Tanaka Asuka Ishihara Akiko Uchizawa Insung Park Kaito Iwayama Hitomi Ogata Katsuhiko Yajima Naomi Omi Makoto Satoh Masashi Yanagisawa Hiroyuki Sagayama Kumpei Tokuyama |
| author_sort | Simeng Zhang |
| collection | DOAJ |
| description | Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility. |
| first_indexed | 2024-12-13T16:50:48Z |
| format | Article |
| id | doaj.art-555456dd18f44553b8daa3a00c51eff0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T16:50:48Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-555456dd18f44553b8daa3a00c51eff02022-12-21T23:38:02ZengNature PortfolioScientific Reports2045-23222021-09-0111111310.1038/s41598-021-97301-8Metabolic flexibility during sleepSimeng Zhang0Yoshiaki Tanaka1Asuka Ishihara2Akiko Uchizawa3Insung Park4Kaito Iwayama5Hitomi Ogata6Katsuhiko Yajima7Naomi Omi8Makoto Satoh9Masashi Yanagisawa10Hiroyuki Sagayama11Kumpei Tokuyama12International Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaDoctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of TsukubaPh.D. Program in Human Biology, Doctoral Program in School of Integrative and Global Majors (SIGMA), University of TsukubaDoctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaFaculty of Budo and Sport Studies, Tenri UniversityGraduate School of Integrated Arts and Sciences, Hiroshima UniversityFaculty of Pharmaceutical Sciences, Josai UniversityFaculty of Health and Sports Sciences, University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaFaculty of Health and Sports Sciences, University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaAbstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.https://doi.org/10.1038/s41598-021-97301-8 |
| spellingShingle | Simeng Zhang Yoshiaki Tanaka Asuka Ishihara Akiko Uchizawa Insung Park Kaito Iwayama Hitomi Ogata Katsuhiko Yajima Naomi Omi Makoto Satoh Masashi Yanagisawa Hiroyuki Sagayama Kumpei Tokuyama Metabolic flexibility during sleep Scientific Reports |
| title | Metabolic flexibility during sleep |
| title_full | Metabolic flexibility during sleep |
| title_fullStr | Metabolic flexibility during sleep |
| title_full_unstemmed | Metabolic flexibility during sleep |
| title_short | Metabolic flexibility during sleep |
| title_sort | metabolic flexibility during sleep |
| url | https://doi.org/10.1038/s41598-021-97301-8 |
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