Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south India
PURPOSE: To describe the ocular manifestations in the acute stage of Stevens-Johnson syndrome/ toxic epidermal necrolysis. MATERIALS AND METHODS: We reviewed all the medical records of patients diagnosed with Stevens-Johnson syndrome/ toxic epidermal necrolysis and erythema multiforme between 2012 a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Taiwan Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2022;volume=12;issue=2;spage=184;epage=190;aulast=Pradeep |
| _version_ | 1811217641659957248 |
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| author | Thanuja Gopal Pradeep Samyakta A Shetti |
| author_facet | Thanuja Gopal Pradeep Samyakta A Shetti |
| author_sort | Thanuja Gopal Pradeep |
| collection | DOAJ |
| description | PURPOSE: To describe the ocular manifestations in the acute stage of Stevens-Johnson syndrome/ toxic epidermal necrolysis.
MATERIALS AND METHODS: We reviewed all the medical records of patients diagnosed with Stevens-Johnson syndrome/ toxic epidermal necrolysis and erythema multiforme between 2012 and 2019. Demographics, ophthalmic manifestations, and the treatment given systemically and locally were reviewed and analyzed.
RESULTS: We had forty-five patients admitted to our hospital between Jan 2012 to Dec 2019 with SJS/TEN as a diagnosis.Twenty-six (57.5%) of them were females, and 19(42.2%) were males. The mean age was 27.5 years.Forty (88.9%) of our cases were diagnosed as Stevens-Johnson syndrome, and five (11.9%) as toxic epidermal necrolysis.We found antiepileptics as a triggering agent in thirteen cases (28.8%).Fever (84.4%) and mucosal lesions (86.7%) were the most common presenting symptom.We found ocular symptoms in only 22 (48.9%) patients.The treating physicians referred only thirty-one cases to the ophthalmologist, out of which 22 cases were referred within three days of admission.The most common ocular involvement was conjunctival congestion (69%).Ocular grading showed that mild grade included 42.9%, moderate grade 28.6%, and severe grade 28.6% of the cases.The ocular treatment involved medical management with lubricating drops (100%), topical steroids (58.6%), and topical antibiotics (68.9%). Five individuals with a severe grade of ocular involvement underwent amniotic membrane transplantation.
CONCLUSION: Ocular examination and grading are essential in the acute stage of SJS/TEN. It helps the ophthalmologist recognize the sentinel findings and institute appropriate treatment in the acute stage as early as possible. |
| first_indexed | 2024-04-12T06:58:11Z |
| format | Article |
| id | doaj.art-555472f1ba21400f909498daab511731 |
| institution | Directory Open Access Journal |
| issn | 2211-5056 2211-5072 |
| language | English |
| last_indexed | 2024-04-12T06:58:11Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwan Journal of Ophthalmology |
| spelling | doaj.art-555472f1ba21400f909498daab5117312022-12-22T03:43:05ZengWolters Kluwer Medknow PublicationsTaiwan Journal of Ophthalmology2211-50562211-50722022-01-0112218419010.4103/tjo.tjo_13_21Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south IndiaThanuja Gopal PradeepSamyakta A ShettiPURPOSE: To describe the ocular manifestations in the acute stage of Stevens-Johnson syndrome/ toxic epidermal necrolysis. MATERIALS AND METHODS: We reviewed all the medical records of patients diagnosed with Stevens-Johnson syndrome/ toxic epidermal necrolysis and erythema multiforme between 2012 and 2019. Demographics, ophthalmic manifestations, and the treatment given systemically and locally were reviewed and analyzed. RESULTS: We had forty-five patients admitted to our hospital between Jan 2012 to Dec 2019 with SJS/TEN as a diagnosis.Twenty-six (57.5%) of them were females, and 19(42.2%) were males. The mean age was 27.5 years.Forty (88.9%) of our cases were diagnosed as Stevens-Johnson syndrome, and five (11.9%) as toxic epidermal necrolysis.We found antiepileptics as a triggering agent in thirteen cases (28.8%).Fever (84.4%) and mucosal lesions (86.7%) were the most common presenting symptom.We found ocular symptoms in only 22 (48.9%) patients.The treating physicians referred only thirty-one cases to the ophthalmologist, out of which 22 cases were referred within three days of admission.The most common ocular involvement was conjunctival congestion (69%).Ocular grading showed that mild grade included 42.9%, moderate grade 28.6%, and severe grade 28.6% of the cases.The ocular treatment involved medical management with lubricating drops (100%), topical steroids (58.6%), and topical antibiotics (68.9%). Five individuals with a severe grade of ocular involvement underwent amniotic membrane transplantation. CONCLUSION: Ocular examination and grading are essential in the acute stage of SJS/TEN. It helps the ophthalmologist recognize the sentinel findings and institute appropriate treatment in the acute stage as early as possible.http://www.e-tjo.org/article.asp?issn=2211-5056;year=2022;volume=12;issue=2;spage=184;epage=190;aulast=Pradeepacute stageamniotic membraneconjunctivitisocular gradingocular manifestationsstevens-johnson syndrometoxic epidermal necrolysis |
| spellingShingle | Thanuja Gopal Pradeep Samyakta A Shetti Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south India Taiwan Journal of Ophthalmology acute stage amniotic membrane conjunctivitis ocular grading ocular manifestations stevens-johnson syndrome toxic epidermal necrolysis |
| title | Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south India |
| title_full | Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south India |
| title_fullStr | Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south India |
| title_full_unstemmed | Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south India |
| title_short | Ocular manifestations in acute stage Stevens-Johnson syndrome/toxic epidermal necrolysis - A retrospective study in a tertiary hospital in south India |
| title_sort | ocular manifestations in acute stage stevens johnson syndrome toxic epidermal necrolysis a retrospective study in a tertiary hospital in south india |
| topic | acute stage amniotic membrane conjunctivitis ocular grading ocular manifestations stevens-johnson syndrome toxic epidermal necrolysis |
| url | http://www.e-tjo.org/article.asp?issn=2211-5056;year=2022;volume=12;issue=2;spage=184;epage=190;aulast=Pradeep |
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