Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children
(1) Background: Immune thrombocytopenia (ITP) is an acute autoimmune blood disorder that is the main cause of thrombocytopenia in children. It is characterized by a decrease in platelets below 100 × 10<sup>9</sup>/L, and limited evolution with severe complications such as intracranial he...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/6/911 |
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| author | Vasile Eduard Rosu Solange Tamara Roșu Anca Viorica Ivanov Iuliana Magdalena Starcea Violeta Streanga Ingrith Crenguta Miron Adriana Mocanu Ancuta Lupu Vasile Valeriu Lupu Cristina Gavrilovici |
| author_facet | Vasile Eduard Rosu Solange Tamara Roșu Anca Viorica Ivanov Iuliana Magdalena Starcea Violeta Streanga Ingrith Crenguta Miron Adriana Mocanu Ancuta Lupu Vasile Valeriu Lupu Cristina Gavrilovici |
| author_sort | Vasile Eduard Rosu |
| collection | DOAJ |
| description | (1) Background: Immune thrombocytopenia (ITP) is an acute autoimmune blood disorder that is the main cause of thrombocytopenia in children. It is characterized by a decrease in platelets below 100 × 10<sup>9</sup>/L, and limited evolution with severe complications such as intracranial hemorrhage. The chronic form is defined by the persistence of thrombocytopenia more than 12 months after diagnosis. (2) Methods: We performed a retrospective study over a period of 10 years (1 January 2011–31 December 2020) at the Emergency Clinical Hospital for Children “Sf. Maria”, Iasi. The aim of the study was to describe the clinical characteristics and to determine the prognostic factors in immune thrombocytopenia in children. (3) Results: In this study we included 271 children with ITP, comprising 123 females (45.4%) and 148 males (54.6%). The remission rate was higher in males, being 68.9% compared to 56.1% in females. Children with ITP under 9 years of age had a higher remission rate. Children with a platelet count > 10 × 10<sup>9</sup>/L at diagnosis had a higher likelihood-of-remission rate compared to patients who presented initial platelet count below this value. (4) Conclusions: The risk factors highly suggestive for chronicity are: age at diagnosis, female sex, and the number of platelets at the onset of the disease. |
| first_indexed | 2024-03-11T02:37:47Z |
| format | Article |
| id | doaj.art-55563d970a6842199a1a9fd6fc541dc4 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T02:37:47Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-55563d970a6842199a1a9fd6fc541dc42023-11-18T09:48:57ZengMDPI AGChildren2227-90672023-05-0110691110.3390/children10060911Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in ChildrenVasile Eduard Rosu0Solange Tamara Roșu1Anca Viorica Ivanov2Iuliana Magdalena Starcea3Violeta Streanga4Ingrith Crenguta Miron5Adriana Mocanu6Ancuta Lupu7Vasile Valeriu Lupu8Cristina Gavrilovici9Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaNursing, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania(1) Background: Immune thrombocytopenia (ITP) is an acute autoimmune blood disorder that is the main cause of thrombocytopenia in children. It is characterized by a decrease in platelets below 100 × 10<sup>9</sup>/L, and limited evolution with severe complications such as intracranial hemorrhage. The chronic form is defined by the persistence of thrombocytopenia more than 12 months after diagnosis. (2) Methods: We performed a retrospective study over a period of 10 years (1 January 2011–31 December 2020) at the Emergency Clinical Hospital for Children “Sf. Maria”, Iasi. The aim of the study was to describe the clinical characteristics and to determine the prognostic factors in immune thrombocytopenia in children. (3) Results: In this study we included 271 children with ITP, comprising 123 females (45.4%) and 148 males (54.6%). The remission rate was higher in males, being 68.9% compared to 56.1% in females. Children with ITP under 9 years of age had a higher remission rate. Children with a platelet count > 10 × 10<sup>9</sup>/L at diagnosis had a higher likelihood-of-remission rate compared to patients who presented initial platelet count below this value. (4) Conclusions: The risk factors highly suggestive for chronicity are: age at diagnosis, female sex, and the number of platelets at the onset of the disease.https://www.mdpi.com/2227-9067/10/6/911immune thrombocytopeniachronic thrombocytopenic purpurachildrisk factors for chronicity |
| spellingShingle | Vasile Eduard Rosu Solange Tamara Roșu Anca Viorica Ivanov Iuliana Magdalena Starcea Violeta Streanga Ingrith Crenguta Miron Adriana Mocanu Ancuta Lupu Vasile Valeriu Lupu Cristina Gavrilovici Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children Children immune thrombocytopenia chronic thrombocytopenic purpura child risk factors for chronicity |
| title | Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children |
| title_full | Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children |
| title_fullStr | Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children |
| title_full_unstemmed | Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children |
| title_short | Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children |
| title_sort | predictor factors for chronicity in immune thrombocytopenic purpura in children |
| topic | immune thrombocytopenia chronic thrombocytopenic purpura child risk factors for chronicity |
| url | https://www.mdpi.com/2227-9067/10/6/911 |
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