Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation
The inter-organelle interactions, including the cytomembrane, endoplasmic reticulum, mitochondrion, lysosome, dictyosome, and nucleus, play the important roles in maintaining the normal function and homeostasis of cells. Organelle dysfunction can lead to a range of diseases (e.g., Alzheimer’s diseas...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.935898/full |
| _version_ | 1828727435960516608 |
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| author | Zhiwei Yang Zhiwei Yang Zichen Zhang Yizhen Zhao Qiushi Ye Xuhua Li Lingjie Meng Lingjie Meng Jiangang Long Shengli Zhang Lei Zhang |
| author_facet | Zhiwei Yang Zhiwei Yang Zichen Zhang Yizhen Zhao Qiushi Ye Xuhua Li Lingjie Meng Lingjie Meng Jiangang Long Shengli Zhang Lei Zhang |
| author_sort | Zhiwei Yang |
| collection | DOAJ |
| description | The inter-organelle interactions, including the cytomembrane, endoplasmic reticulum, mitochondrion, lysosome, dictyosome, and nucleus, play the important roles in maintaining the normal function and homeostasis of cells. Organelle dysfunction can lead to a range of diseases (e.g., Alzheimer’s disease (AD), Parkinson’s disease (PD), and cancer), and provide a new perspective for drug discovery. With the development of imaging techniques and functional fluorescent probes, a variety of algorithms and strategies have been developed for the ever-improving estimation of subcellular structures, organelle interaction, and organelle-related drug discovery with accounting for the dynamic structures of organelles, such as the nanoscopy technology and molecular dynamics (MD) simulations. Accordingly, this work summarizes a series of state-of-the-art examples of the recent progress in this rapidly changing field and uncovering the drug screening based on the structures and interactions of organelles. Finally, we propose the future outlook for exciting applications of organelle-related drug discovery, with the cooperation of nanoscopy and MD simulations. |
| first_indexed | 2024-04-12T13:57:48Z |
| format | Article |
| id | doaj.art-5556960ef8c444cb86822d64b1a743e4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T13:57:48Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5556960ef8c444cb86822d64b1a743e42022-12-22T03:30:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-06-011310.3389/fphar.2022.935898935898Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics SimulationZhiwei Yang0Zhiwei Yang1Zichen Zhang2Yizhen Zhao3Qiushi Ye4Xuhua Li5Lingjie Meng6Lingjie Meng7Jiangang Long8Shengli Zhang9Lei Zhang10MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an, ChinaMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, ChinaMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, ChinaMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, ChinaMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, ChinaSchool of Chemistry, Xi’an Jiaotong University, Xi’an, ChinaInstrumental Analysis Center, Xi’an Jiaotong University, Xi’an, ChinaSchool of Life Science and Technology, Xi’an Jiaotong University, Xi’an, ChinaMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, ChinaMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an, ChinaThe inter-organelle interactions, including the cytomembrane, endoplasmic reticulum, mitochondrion, lysosome, dictyosome, and nucleus, play the important roles in maintaining the normal function and homeostasis of cells. Organelle dysfunction can lead to a range of diseases (e.g., Alzheimer’s disease (AD), Parkinson’s disease (PD), and cancer), and provide a new perspective for drug discovery. With the development of imaging techniques and functional fluorescent probes, a variety of algorithms and strategies have been developed for the ever-improving estimation of subcellular structures, organelle interaction, and organelle-related drug discovery with accounting for the dynamic structures of organelles, such as the nanoscopy technology and molecular dynamics (MD) simulations. Accordingly, this work summarizes a series of state-of-the-art examples of the recent progress in this rapidly changing field and uncovering the drug screening based on the structures and interactions of organelles. Finally, we propose the future outlook for exciting applications of organelle-related drug discovery, with the cooperation of nanoscopy and MD simulations.https://www.frontiersin.org/articles/10.3389/fphar.2022.935898/fullorganelle interactionsubcellular structuredrug discoverynanoscopymolecular dynamics simulation |
| spellingShingle | Zhiwei Yang Zhiwei Yang Zichen Zhang Yizhen Zhao Qiushi Ye Xuhua Li Lingjie Meng Lingjie Meng Jiangang Long Shengli Zhang Lei Zhang Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation Frontiers in Pharmacology organelle interaction subcellular structure drug discovery nanoscopy molecular dynamics simulation |
| title | Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation |
| title_full | Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation |
| title_fullStr | Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation |
| title_full_unstemmed | Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation |
| title_short | Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation |
| title_sort | organelle interaction and drug discovery towards correlative nanoscopy and molecular dynamics simulation |
| topic | organelle interaction subcellular structure drug discovery nanoscopy molecular dynamics simulation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.935898/full |
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