Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infant
Reports on the clinical course of fetal umbilical vein varix in premature infants are limited. We report a case of an extremely low body weight infant with intra-abdominal umbilical vein varix who developed disseminated intravascular coagulation, polycythemia, and hyperbilirubinemia after birth; lat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1154820/full |
| _version_ | 1797856351019335680 |
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| author | Mariko Sekiguchi Takeo Mukai Yoshihiko Shitara Kohei Kashima Takahiro Seyama Keiichi Kumasawa Naoto Takahashi |
| author_facet | Mariko Sekiguchi Takeo Mukai Yoshihiko Shitara Kohei Kashima Takahiro Seyama Keiichi Kumasawa Naoto Takahashi |
| author_sort | Mariko Sekiguchi |
| collection | DOAJ |
| description | Reports on the clinical course of fetal umbilical vein varix in premature infants are limited. We report a case of an extremely low body weight infant with intra-abdominal umbilical vein varix who developed disseminated intravascular coagulation, polycythemia, and hyperbilirubinemia after birth; late-onset neonatal hepatitis; and fetal thrombotic vasculopathy confirmed by placental histopathology. Ultrasonography after birth showed a dilated portion of the umbilical vein at the hepatic hilum with thrombi inside. We speculate that the umbilical vein varix caused the fetal thrombotic vasculopathy, and the presence of umbilical vein varix and fetal thrombotic vasculopathy in combination with prematurity caused coagulopathy, polycythemia, hyperbilirubinemia, and hepatitis. Despite the favorable outcomes reported in the literature, premature infants with umbilical vein varix may require careful observation and management for coagulopathy and late-onset hepatitis. Furthermore, placental histopathology could aid in the understanding of various clinical outcomes in infants with umbilical vein varices. |
| first_indexed | 2024-04-09T20:38:59Z |
| format | Article |
| id | doaj.art-5556bdea0fc144158aaf9fd4a73b36d0 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T20:38:59Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-5556bdea0fc144158aaf9fd4a73b36d02023-03-30T06:04:01ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.11548201154820Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infantMariko Sekiguchi0Takeo Mukai1Yoshihiko Shitara2Kohei Kashima3Takahiro Seyama4Keiichi Kumasawa5Naoto Takahashi6Department of Pediatrics, The University of Tokyo Hospital, Tokyo, JapanDepartment of Pediatrics, The University of Tokyo Hospital, Tokyo, JapanDepartment of Pediatrics, The University of Tokyo Hospital, Tokyo, JapanDepartment of Pediatrics, The University of Tokyo Hospital, Tokyo, JapanDepartment of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo, JapanDepartment of Obstetrics and Gynecology, The University of Tokyo Hospital, Tokyo, JapanDepartment of Pediatrics, The University of Tokyo Hospital, Tokyo, JapanReports on the clinical course of fetal umbilical vein varix in premature infants are limited. We report a case of an extremely low body weight infant with intra-abdominal umbilical vein varix who developed disseminated intravascular coagulation, polycythemia, and hyperbilirubinemia after birth; late-onset neonatal hepatitis; and fetal thrombotic vasculopathy confirmed by placental histopathology. Ultrasonography after birth showed a dilated portion of the umbilical vein at the hepatic hilum with thrombi inside. We speculate that the umbilical vein varix caused the fetal thrombotic vasculopathy, and the presence of umbilical vein varix and fetal thrombotic vasculopathy in combination with prematurity caused coagulopathy, polycythemia, hyperbilirubinemia, and hepatitis. Despite the favorable outcomes reported in the literature, premature infants with umbilical vein varix may require careful observation and management for coagulopathy and late-onset hepatitis. Furthermore, placental histopathology could aid in the understanding of various clinical outcomes in infants with umbilical vein varices.https://www.frontiersin.org/articles/10.3389/fped.2023.1154820/fullumbilical vein varixextremely low birth infantspolycytemianeonatal hepatitisdisseminated intravascular coagulationfetal thrombotic vasculopathy |
| spellingShingle | Mariko Sekiguchi Takeo Mukai Yoshihiko Shitara Kohei Kashima Takahiro Seyama Keiichi Kumasawa Naoto Takahashi Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infant Frontiers in Pediatrics umbilical vein varix extremely low birth infants polycytemia neonatal hepatitis disseminated intravascular coagulation fetal thrombotic vasculopathy |
| title | Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infant |
| title_full | Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infant |
| title_fullStr | Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infant |
| title_full_unstemmed | Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infant |
| title_short | Case report: A case of fetal umbilical vein varix presenting disseminated intravascular coagulation, polycythemia, and neonatal hepatitis in an extremely low birth weight infant |
| title_sort | case report a case of fetal umbilical vein varix presenting disseminated intravascular coagulation polycythemia and neonatal hepatitis in an extremely low birth weight infant |
| topic | umbilical vein varix extremely low birth infants polycytemia neonatal hepatitis disseminated intravascular coagulation fetal thrombotic vasculopathy |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1154820/full |
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