Small cell lung cancer with dermatomyositis: a case report
Dermatomyositis represents an autoimmune disorder characterized by notable skin and muscular manifestations. The annual incidence of dermatomyositis stands at approximately (5~10)/1 million individuals. Notably, patients with malignant tumors exhibit an elevated risk of developing dermatomyositis co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1325991/full |
| _version_ | 1797314440785297408 |
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| author | Xiaomin Guan Shi Qiu Yinghui Xu Jianjiao Zu Chao Sun Ye Guo Xu Wang Kewei Ma |
| author_facet | Xiaomin Guan Shi Qiu Yinghui Xu Jianjiao Zu Chao Sun Ye Guo Xu Wang Kewei Ma |
| author_sort | Xiaomin Guan |
| collection | DOAJ |
| description | Dermatomyositis represents an autoimmune disorder characterized by notable skin and muscular manifestations. The annual incidence of dermatomyositis stands at approximately (5~10)/1 million individuals. Notably, patients with malignant tumors exhibit an elevated risk of developing dermatomyositis compared to the general population. However, in cases where dermatomyositis co-occurs with malignancy, the efficacy of hormone therapy alone tends to be suboptimal. Moreover, reports addressing the correlation between tumor treatment and the management of dermatomyositis are scarce. A 60-year-old male patient presented with dermatomyositis, initially manifesting through symptoms such as rash, muscle weakness, and dysphagia. Despite undergoing standard hormone therapy, there was no discernible improvement in the dermatomyositis symptoms. Considering the patient’s concomitant troublesome cough, further investigations were conducted, including CT, PET-CT, and pathological biopsy. These assessments confirmed the diagnosis of limited-stage small cell lung cancer (T1cN3M0 IIIB). Notably, in this patient, dermatomyositis was suspected to be a paraneoplastic syndrome associated with small cell lung cancer. Standard chemotherapy and radiotherapy were employed to treat the small cell lung cancer, resulting in partial remission after two treatment cycles. As the malignancy regressed, a notable improvement in dermatomyositis symptoms was observed, subsequently leading to a gradual reduction in the prescribed hormone dosage. In conclusion, we present a comprehensive case study of dermatomyositis as a paraneoplastic syndrome throughout the treatment process. The response to tumor therapy coincided with the amelioration of dermatomyositis symptoms. Therefore, diligent malignancy screening is imperative for patients diagnosed with dermatomyositis. |
| first_indexed | 2024-03-08T02:47:10Z |
| format | Article |
| id | doaj.art-5556f36f5310418f86419dc4d73029fd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T02:47:10Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5556f36f5310418f86419dc4d73029fd2024-02-13T13:18:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.13259911325991Small cell lung cancer with dermatomyositis: a case reportXiaomin Guan0Shi Qiu1Yinghui Xu2Jianjiao Zu3Chao Sun4Ye Guo5Xu Wang6Kewei Ma7Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaCancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaCancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDermatology Department, The First Hospital of Jilin University, Changchun, Jilin, ChinaCancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaCancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaCancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaCancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDermatomyositis represents an autoimmune disorder characterized by notable skin and muscular manifestations. The annual incidence of dermatomyositis stands at approximately (5~10)/1 million individuals. Notably, patients with malignant tumors exhibit an elevated risk of developing dermatomyositis compared to the general population. However, in cases where dermatomyositis co-occurs with malignancy, the efficacy of hormone therapy alone tends to be suboptimal. Moreover, reports addressing the correlation between tumor treatment and the management of dermatomyositis are scarce. A 60-year-old male patient presented with dermatomyositis, initially manifesting through symptoms such as rash, muscle weakness, and dysphagia. Despite undergoing standard hormone therapy, there was no discernible improvement in the dermatomyositis symptoms. Considering the patient’s concomitant troublesome cough, further investigations were conducted, including CT, PET-CT, and pathological biopsy. These assessments confirmed the diagnosis of limited-stage small cell lung cancer (T1cN3M0 IIIB). Notably, in this patient, dermatomyositis was suspected to be a paraneoplastic syndrome associated with small cell lung cancer. Standard chemotherapy and radiotherapy were employed to treat the small cell lung cancer, resulting in partial remission after two treatment cycles. As the malignancy regressed, a notable improvement in dermatomyositis symptoms was observed, subsequently leading to a gradual reduction in the prescribed hormone dosage. In conclusion, we present a comprehensive case study of dermatomyositis as a paraneoplastic syndrome throughout the treatment process. The response to tumor therapy coincided with the amelioration of dermatomyositis symptoms. Therefore, diligent malignancy screening is imperative for patients diagnosed with dermatomyositis.https://www.frontiersin.org/articles/10.3389/fonc.2024.1325991/fullSCLCsmall cell lung cancerlung cancerparaneoplastic syndromedermatomyositis |
| spellingShingle | Xiaomin Guan Shi Qiu Yinghui Xu Jianjiao Zu Chao Sun Ye Guo Xu Wang Kewei Ma Small cell lung cancer with dermatomyositis: a case report Frontiers in Oncology SCLC small cell lung cancer lung cancer paraneoplastic syndrome dermatomyositis |
| title | Small cell lung cancer with dermatomyositis: a case report |
| title_full | Small cell lung cancer with dermatomyositis: a case report |
| title_fullStr | Small cell lung cancer with dermatomyositis: a case report |
| title_full_unstemmed | Small cell lung cancer with dermatomyositis: a case report |
| title_short | Small cell lung cancer with dermatomyositis: a case report |
| title_sort | small cell lung cancer with dermatomyositis a case report |
| topic | SCLC small cell lung cancer lung cancer paraneoplastic syndrome dermatomyositis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1325991/full |
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