Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe
Abstract Background To evaluate the accuracy of intravitreal injection volume of the pre-filled syringe (PFS) in which aflibercept is packaged compared to the BD Luer-Lok 1-mL syringe. Methods Ophthalmologists injected their typical intravitreal volume for aflibercept using either the PFS or BD Luer...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-04-01
|
| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40942-022-00375-3 |
| _version_ | 1819061343327617024 |
|---|---|
| author | John-Michael Guest Brett Malbin Gary Abrams Anthony Parendo Shibandri Das Chinwenwa Okeagu Bing X. Ross Ashok Kumar Xihui Lin |
| author_facet | John-Michael Guest Brett Malbin Gary Abrams Anthony Parendo Shibandri Das Chinwenwa Okeagu Bing X. Ross Ashok Kumar Xihui Lin |
| author_sort | John-Michael Guest |
| collection | DOAJ |
| description | Abstract Background To evaluate the accuracy of intravitreal injection volume of the pre-filled syringe (PFS) in which aflibercept is packaged compared to the BD Luer-Lok 1-mL syringe. Methods Ophthalmologists injected their typical intravitreal volume for aflibercept using either the PFS or BD Luer-Lok 1-mL syringe for 5 times each. The injected fluid was weighed using a micro-scale and converted to volume. The volume of fluid injected was also evaluated when the 0.05 mL line on the PFS was lined up to the tip or base of the dome-shaped plunger. Results Injection volume was measured for 12 physicians. The average injected fluid volume was 74.22 ± 15.87 µL for PFS and 53.42 ± 4.61 µL for the BD Luer-Lok 1-mL syringe (p < 0.0001). The average deviation in volume injected for the PFS was higher compared to the BD Luer-Lok 1-mL syringe (11.36 µL vs. 3.35 µL, p < 0.0001). When the PFS was lined up with the tip of the dome-shaped plunger at the 0.05-mL line, the average injected volume was 71.03% higher. Conclusions The intravitreal injection volume and variability using the new PFS were significantly higher than the volume injected using the BD Luer-Lok 1-mL syringe previously used, potentially leading to higher rates of visually significant elevation of intraocular pressures. |
| first_indexed | 2024-12-21T14:41:23Z |
| format | Article |
| id | doaj.art-5559267427d34eebb16d6c3dbd2225db |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-21T14:41:23Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-5559267427d34eebb16d6c3dbd2225db2022-12-21T19:00:11ZengBMCInternational Journal of Retina and Vitreous2056-99202022-04-01811510.1186/s40942-022-00375-3Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringeJohn-Michael Guest0Brett Malbin1Gary Abrams2Anthony Parendo3Shibandri Das4Chinwenwa Okeagu5Bing X. Ross6Ashok Kumar7Xihui Lin8Kresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineKresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of MedicineAbstract Background To evaluate the accuracy of intravitreal injection volume of the pre-filled syringe (PFS) in which aflibercept is packaged compared to the BD Luer-Lok 1-mL syringe. Methods Ophthalmologists injected their typical intravitreal volume for aflibercept using either the PFS or BD Luer-Lok 1-mL syringe for 5 times each. The injected fluid was weighed using a micro-scale and converted to volume. The volume of fluid injected was also evaluated when the 0.05 mL line on the PFS was lined up to the tip or base of the dome-shaped plunger. Results Injection volume was measured for 12 physicians. The average injected fluid volume was 74.22 ± 15.87 µL for PFS and 53.42 ± 4.61 µL for the BD Luer-Lok 1-mL syringe (p < 0.0001). The average deviation in volume injected for the PFS was higher compared to the BD Luer-Lok 1-mL syringe (11.36 µL vs. 3.35 µL, p < 0.0001). When the PFS was lined up with the tip of the dome-shaped plunger at the 0.05-mL line, the average injected volume was 71.03% higher. Conclusions The intravitreal injection volume and variability using the new PFS were significantly higher than the volume injected using the BD Luer-Lok 1-mL syringe previously used, potentially leading to higher rates of visually significant elevation of intraocular pressures.https://doi.org/10.1186/s40942-022-00375-3AfliberceptIntravitreal injectionPre-filled syringe |
| spellingShingle | John-Michael Guest Brett Malbin Gary Abrams Anthony Parendo Shibandri Das Chinwenwa Okeagu Bing X. Ross Ashok Kumar Xihui Lin Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe International Journal of Retina and Vitreous Aflibercept Intravitreal injection Pre-filled syringe |
| title | Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe |
| title_full | Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe |
| title_fullStr | Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe |
| title_full_unstemmed | Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe |
| title_short | Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe |
| title_sort | accuracy of intravitreal injection volume for aflibercept pre filled syringe and bd luer lok one milliliter syringe |
| topic | Aflibercept Intravitreal injection Pre-filled syringe |
| url | https://doi.org/10.1186/s40942-022-00375-3 |
| work_keys_str_mv | AT johnmichaelguest accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT brettmalbin accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT garyabrams accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT anthonyparendo accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT shibandridas accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT chinwenwaokeagu accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT bingxross accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT ashokkumar accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe AT xihuilin accuracyofintravitrealinjectionvolumeforafliberceptprefilledsyringeandbdluerlokonemillilitersyringe |