Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study
Abstract Background Cardiovascular diseases are more prevalent and severe in Asian Indians. Simple diet-based strategies are important for prevention of cardiovascular diseases.The aim of the present study was to evaluate the effects of oats consumption on lipid parameters in mildly hypercholesterol...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-04-01
|
| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-017-0460-3 |
| _version_ | 1828369683999358976 |
|---|---|
| author | Seema Gulati Anoop Misra Ravindra M Pandey |
| author_facet | Seema Gulati Anoop Misra Ravindra M Pandey |
| author_sort | Seema Gulati |
| collection | DOAJ |
| description | Abstract Background Cardiovascular diseases are more prevalent and severe in Asian Indians. Simple diet-based strategies are important for prevention of cardiovascular diseases.The aim of the present study was to evaluate the effects of oats consumption on lipid parameters in mildly hypercholesterolemic Asian Indians living in India. Methods A short-term, prospective, open-labeled, randomized controlled, parallel group study was conducted. Mildly hypercholesterolemic (total cholesterol >200 mg/dL and <240 mg/dL) subjects (n = 80) were randomized into two groups: intervention (n = 40) and usual diet (n = 40). Sample size was calculated for a two-group parallel superiority randomized control trial. Out of 80 enrolled subjects 69 subjects completed the study; 33 in the control group and 36 in the intervention group. In the intervention group, patients were served 70 g of oats twice a day in the form of porridge and upma (A thick porridge from oats with seasonings and vegetables) under observation at the study site. Lipid parameters were assessed at baseline and after 4 weeks of intervention. Results There was a reduction of 3.1% in total cholesterol levels in the control group as against 8.1% reduction in the intervention group (p < 0.02). Greater reductions were also seen in low-density lipoprotein cholesterol in the intervention group (11.6%) as compared to control group (4.1%, p < 0.04) over a period of 28 days. Conclusion Daily consumption of 3 g of soluble fiber from 70 g of oats leads to beneficial effects on the lipid parameters, specifically total cholesterol and low-density lipoprotein cholesterol in hypercholesterolemic Asian Indians. Large scale studies over a longer period of intervention are required to further establish the cholesterol-lowering effect of oat fiber. Trial registration The study was retrospectively registered at clinicaltrials.gov (dated: 25th Februrary.2015) with registration number NCT02376660 . |
| first_indexed | 2024-04-14T06:27:55Z |
| format | Article |
| id | doaj.art-5559878b8716464a90dc26ae568c7afc |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-14T06:27:55Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-5559878b8716464a90dc26ae568c7afc2022-12-22T02:07:43ZengBMCLipids in Health and Disease1476-511X2017-04-011611810.1186/s12944-017-0460-3Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm studySeema Gulati0Anoop Misra1Ravindra M Pandey2Diabetes Foundation (India), Safdarjung Development AreaDiabetes Foundation (India), Safdarjung Development AreaAll India Institute of Medical Sciences (AIIMS)Abstract Background Cardiovascular diseases are more prevalent and severe in Asian Indians. Simple diet-based strategies are important for prevention of cardiovascular diseases.The aim of the present study was to evaluate the effects of oats consumption on lipid parameters in mildly hypercholesterolemic Asian Indians living in India. Methods A short-term, prospective, open-labeled, randomized controlled, parallel group study was conducted. Mildly hypercholesterolemic (total cholesterol >200 mg/dL and <240 mg/dL) subjects (n = 80) were randomized into two groups: intervention (n = 40) and usual diet (n = 40). Sample size was calculated for a two-group parallel superiority randomized control trial. Out of 80 enrolled subjects 69 subjects completed the study; 33 in the control group and 36 in the intervention group. In the intervention group, patients were served 70 g of oats twice a day in the form of porridge and upma (A thick porridge from oats with seasonings and vegetables) under observation at the study site. Lipid parameters were assessed at baseline and after 4 weeks of intervention. Results There was a reduction of 3.1% in total cholesterol levels in the control group as against 8.1% reduction in the intervention group (p < 0.02). Greater reductions were also seen in low-density lipoprotein cholesterol in the intervention group (11.6%) as compared to control group (4.1%, p < 0.04) over a period of 28 days. Conclusion Daily consumption of 3 g of soluble fiber from 70 g of oats leads to beneficial effects on the lipid parameters, specifically total cholesterol and low-density lipoprotein cholesterol in hypercholesterolemic Asian Indians. Large scale studies over a longer period of intervention are required to further establish the cholesterol-lowering effect of oat fiber. Trial registration The study was retrospectively registered at clinicaltrials.gov (dated: 25th Februrary.2015) with registration number NCT02376660 .http://link.springer.com/article/10.1186/s12944-017-0460-3Total CholesterolBile AcidGlucanSerum TriglycerideTotal Cholesterol Level |
| spellingShingle | Seema Gulati Anoop Misra Ravindra M Pandey Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study Lipids in Health and Disease Total Cholesterol Bile Acid Glucan Serum Triglyceride Total Cholesterol Level |
| title | Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study |
| title_full | Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study |
| title_fullStr | Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study |
| title_full_unstemmed | Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study |
| title_short | Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study |
| title_sort | effects of 3 g of soluble fiber from oats on lipid levels of asian indians a randomized controlled parallel arm study |
| topic | Total Cholesterol Bile Acid Glucan Serum Triglyceride Total Cholesterol Level |
| url | http://link.springer.com/article/10.1186/s12944-017-0460-3 |
| work_keys_str_mv | AT seemagulati effectsof3gofsolublefiberfromoatsonlipidlevelsofasianindiansarandomizedcontrolledparallelarmstudy AT anoopmisra effectsof3gofsolublefiberfromoatsonlipidlevelsofasianindiansarandomizedcontrolledparallelarmstudy AT ravindrampandey effectsof3gofsolublefiberfromoatsonlipidlevelsofasianindiansarandomizedcontrolledparallelarmstudy |