Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control Study

Background: Thyroid hormone metabolism is linked to iron metabolism. Thyroperoxidase, a key enzyme in the biosynthesis of thyroid hormones, is iron-dependent. Thus, iron deficiency might be the primary cause of hypothyroidism. Copper is another trace element that has been linked to thyroid status. C...

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Main Authors: Priyanka Thapa Manger, Gyanendra Kumar Yadav, Dhananjay Tiwari, Richa Awasthi, Durga Prasad Verma
Format: Article
Language:English
Published: Cell and BioPharmaceutical Institute 2023-11-01
Series:MCBS (Molecular and Cellular Biomedical Sciences)
Online Access:https://cellbiopharm.com/ojs/index.php/MCBS/article/view/336
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author Priyanka Thapa Manger
Gyanendra Kumar Yadav
Dhananjay Tiwari
Richa Awasthi
Durga Prasad Verma
author_facet Priyanka Thapa Manger
Gyanendra Kumar Yadav
Dhananjay Tiwari
Richa Awasthi
Durga Prasad Verma
author_sort Priyanka Thapa Manger
collection DOAJ
description Background: Thyroid hormone metabolism is linked to iron metabolism. Thyroperoxidase, a key enzyme in the biosynthesis of thyroid hormones, is iron-dependent. Thus, iron deficiency might be the primary cause of hypothyroidism. Copper is another trace element that has been linked to thyroid status. Copper regulates excessive thyroxine (T4) absorption and reduces cell damage during thyroid hormone synthesis. The present study clarified the possible correlations between iron and copper levels as well as total iron binding capacity (TIBC) and triiodothyronine (T3), T4, as well as thyroid-stimulating hormone (TSH) levels in healthy and hypothyroid subjects. Materials and methods: Thirty-five healthy subjects and 35 hypothyroid subjects were included in this study. Serum T3, T4, and TSH levels were measured using the enzyme linked fluorescence assay. Serum iron levels and TIBC were estimated using ferrozine/magnesium carbonate method, while serum copper levels were estimated using colorimetric method. Results: Copper levels were not significantly different between healthy and hypothyroid subjects. Iron and T4 levels were significantly lower in hypothyroid subjects compared with those in healthy subjects, while TIBC and TSH levels were significantly higher. There was no significant correlation between copper levels and T3, T4, and TSH levels. Conclusion: There were inverse correlations between TIBC and T4 as well as iron levels, and there was no significant correlation between copper levels and all thyroid function parameters. Routine examination of iron levels and thyroid function is highly recommended for early diagnosis and therapy of hypothyroidism. Keywords: total iron binding capacity, iron, copper, hypothyroidism
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spelling doaj.art-555bdbad54fd4effa1e7a63c25160a852023-11-17T09:51:46ZengCell and BioPharmaceutical InstituteMCBS (Molecular and Cellular Biomedical Sciences)2527-43842527-34422023-11-0173141610.21705/mcbs.v7i3.336122Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control StudyPriyanka Thapa Manger0Gyanendra Kumar Yadav1Dhananjay Tiwari2Richa Awasthi3Durga Prasad Verma4Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, LucknowDepartment of Biochemistry, Index Medical College Hospital & Research Centre, IndoreDepartment of Biochemistry, Prasad Institute of Medical Sciences, LucknowDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, LucknowDepartment of Medicine, Integral Institute of Medical Sciences and Research, Integral University, LucknowBackground: Thyroid hormone metabolism is linked to iron metabolism. Thyroperoxidase, a key enzyme in the biosynthesis of thyroid hormones, is iron-dependent. Thus, iron deficiency might be the primary cause of hypothyroidism. Copper is another trace element that has been linked to thyroid status. Copper regulates excessive thyroxine (T4) absorption and reduces cell damage during thyroid hormone synthesis. The present study clarified the possible correlations between iron and copper levels as well as total iron binding capacity (TIBC) and triiodothyronine (T3), T4, as well as thyroid-stimulating hormone (TSH) levels in healthy and hypothyroid subjects. Materials and methods: Thirty-five healthy subjects and 35 hypothyroid subjects were included in this study. Serum T3, T4, and TSH levels were measured using the enzyme linked fluorescence assay. Serum iron levels and TIBC were estimated using ferrozine/magnesium carbonate method, while serum copper levels were estimated using colorimetric method. Results: Copper levels were not significantly different between healthy and hypothyroid subjects. Iron and T4 levels were significantly lower in hypothyroid subjects compared with those in healthy subjects, while TIBC and TSH levels were significantly higher. There was no significant correlation between copper levels and T3, T4, and TSH levels. Conclusion: There were inverse correlations between TIBC and T4 as well as iron levels, and there was no significant correlation between copper levels and all thyroid function parameters. Routine examination of iron levels and thyroid function is highly recommended for early diagnosis and therapy of hypothyroidism. Keywords: total iron binding capacity, iron, copper, hypothyroidismhttps://cellbiopharm.com/ojs/index.php/MCBS/article/view/336
spellingShingle Priyanka Thapa Manger
Gyanendra Kumar Yadav
Dhananjay Tiwari
Richa Awasthi
Durga Prasad Verma
Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control Study
MCBS (Molecular and Cellular Biomedical Sciences)
title Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control Study
title_full Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control Study
title_fullStr Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control Study
title_full_unstemmed Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control Study
title_short Serum Copper, Iron, and Total Iron Binding Capacity in Hypothyroidism: A Case Control Study
title_sort serum copper iron and total iron binding capacity in hypothyroidism a case control study
url https://cellbiopharm.com/ojs/index.php/MCBS/article/view/336
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AT richaawasthi serumcopperironandtotalironbindingcapacityinhypothyroidismacasecontrolstudy
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