Association between Serum Uric Acid Levels and Primary Open-angle Glaucoma: A Cross-sectional Study
Introduction: There is an intricate association between serum Uric Acid (UA) levels and Primary Open Angle Glaucoma (POAG). UA levels in the blood are known to be a good indicator of antioxidant function, and a decrease in UA plays a key role in the pathogenesis of POAG. However, the association...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18670/63326_CE[Ra1]_F(SS)_QC(KK_SS)_PF1(HB_SS)_PFA(HB_KM)_PN(KM).pdf |
| Summary: | Introduction: There is an intricate association between serum
Uric Acid (UA) levels and Primary Open Angle Glaucoma
(POAG). UA levels in the blood are known to be a good indicator
of antioxidant function, and a decrease in UA plays a key role in
the pathogenesis of POAG. However, the association of serum
UA and Uric Acid Creatinine Ratio (UACR) in POAG cases in the
Indian population remains unexplored.
Aim: To investigate the association of serum UA levels and
serum UACR with POAG.
Materials and Methods: This cross-sectional study was
conducted among patients who attended the Outpatient
Department (OPD) of Opthalmology at Maharajah’s Institute
of Medical Sciences, Vizianagaram, Andhra Pradesh, India.
The duration of the study was one year and six months, from
January 15, 2021 to July 15, 2022. The study included 200
recently diagnosed patients with POAG, who were divided into
three groups based on Intraocular Pressure (IOP): Group 1 (mild)
with an IOP of 21-30 mmHg, group 2 (moderate) with an IOP of
31-50 mmHg, and group 3 (severe) with an IOP greater than
51 mmHg. Age and gender-matched 199 healthy subjects were
included as the control group. Blood samples were collected
from the study subjects after obtaining informed consent and
were tested for serum UA (using the modified Trinder method)
and serum creatinine (using Jaffe’s method) in a semiautomatic
analyser (Erba chem 7). The data were analysed using Statistical
Package for Social Sciences (SPSS) version 21.0 software and
MS Excel 2007.
Results: The mean age of the study participants of all three
groups was found to be 51.19±5.06 years with 46.7% male and
53.3% female subjects. The serum UA levels were 5.55±0.74
mg/dL in the mild POAG group, 4.1±0.5 mg/dL in the moderate
POAG group, and 2.67±0.6 mg/dL in the severe POAG group
(p-value <0.001). The present study also found that among the
three study groups of POAG, UA levels were the lowest in the
severe POAG group, followed by the moderate POAG group,
and then the mild POAG group. This pattern was observed in
both the males and females population.
Conclusion: The present study found that serum UA levels were
decreased in POAG patients compared to the normal healthy
control group. Furthermore, the study revealed a significant
negative association between serum UA levels and serum
UACR levels with the severity of POAG. |
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| ISSN: | 2249-782X 0973-709X |