Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in mice
Introduction: Postpartum depression has harmful effects on mother and infant. Regarding the sedative effects of infusion Lippia citriodora (L.C) or lemon verbena in traditional medicine, this study was performed with aim to evaluate the effects of aqueous and alcoholic leave extracts of L.C on postp...
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| Format: | Article |
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Mashhad University of Medical Sciences
2021-12-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_19532_baa523cf4586439c713d598973f83b67.pdf |
| _version_ | 1811223638013116416 |
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| author | Hossein Hosseinzadeh Sepideh Alimoradi Bibi Marjan Razavi |
| author_facet | Hossein Hosseinzadeh Sepideh Alimoradi Bibi Marjan Razavi |
| author_sort | Hossein Hosseinzadeh |
| collection | DOAJ |
| description | Introduction: Postpartum depression has harmful effects on mother and infant. Regarding the sedative effects of infusion Lippia citriodora (L.C) or lemon verbena in traditional medicine, this study was performed with aim to evaluate the effects of aqueous and alcoholic leave extracts of L.C on postpartum depression.
Methods: This animal study was performed in 2018 on female mice in Mashhad Pharmacy School. At first, postpartum depression was induced by progesterone injection (IP) (progesterone at a dose of 5 mg/kg/day for five days, three days without progesterone, then normal saline was injected at eight day). After depression induction (compare with control group, and doing the FST (forced swimming test) and TST (tail suspension test)), the aqueous and ethanolic leave extracts of Lippia citriodora (50,100 and 200 mg/Kg) were injected (IP) to depressed mice in different groups and then TST and FST were performed after one hour. Statistical analysis was performed by Unpaired T test and One-way ANOVA using GraphPad Prism software. A P value of <0.05 was considered statistically significant.
Results: The aqueous (200 mg/kg) and ethanolic (100 mg/kg and 200 mg/kg) extracts significantly reduced the immobility time in FST and TST tests (p<0.0001).
Conclusion: The aqueous and ethanolic leave extracts of L.C possess anti-depressant effects in postpartum depression. It seems that the ethanolic extract of LC is more potent than the aqueous extract due to the high level of verbascoside. |
| first_indexed | 2024-04-12T08:36:13Z |
| format | Article |
| id | doaj.art-555d26a4a1c0466388399bae45e24ff5 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-12T08:36:13Z |
| publishDate | 2021-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-555d26a4a1c0466388399bae45e24ff52022-12-22T03:40:01ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632021-12-0124111910.22038/ijogi.2021.1953219532Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in miceHossein Hosseinzadeh0Sepideh Alimoradi1Bibi Marjan Razavi2Professor of Pharmacology, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Pharmaceutical Sciences Research Center, New Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.general practitioner of pharmacy, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Targeted Drug Delivery Research Center, New Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Postpartum depression has harmful effects on mother and infant. Regarding the sedative effects of infusion Lippia citriodora (L.C) or lemon verbena in traditional medicine, this study was performed with aim to evaluate the effects of aqueous and alcoholic leave extracts of L.C on postpartum depression. Methods: This animal study was performed in 2018 on female mice in Mashhad Pharmacy School. At first, postpartum depression was induced by progesterone injection (IP) (progesterone at a dose of 5 mg/kg/day for five days, three days without progesterone, then normal saline was injected at eight day). After depression induction (compare with control group, and doing the FST (forced swimming test) and TST (tail suspension test)), the aqueous and ethanolic leave extracts of Lippia citriodora (50,100 and 200 mg/Kg) were injected (IP) to depressed mice in different groups and then TST and FST were performed after one hour. Statistical analysis was performed by Unpaired T test and One-way ANOVA using GraphPad Prism software. A P value of <0.05 was considered statistically significant. Results: The aqueous (200 mg/kg) and ethanolic (100 mg/kg and 200 mg/kg) extracts significantly reduced the immobility time in FST and TST tests (p<0.0001). Conclusion: The aqueous and ethanolic leave extracts of L.C possess anti-depressant effects in postpartum depression. It seems that the ethanolic extract of LC is more potent than the aqueous extract due to the high level of verbascoside.https://ijogi.mums.ac.ir/article_19532_baa523cf4586439c713d598973f83b67.pdfdepressionforced-swim testlippia citriodorapostpartum depression |
| spellingShingle | Hossein Hosseinzadeh Sepideh Alimoradi Bibi Marjan Razavi Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in mice Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān depression forced-swim test lippia citriodora postpartum depression |
| title | Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in mice |
| title_full | Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in mice |
| title_fullStr | Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in mice |
| title_full_unstemmed | Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in mice |
| title_short | Antidepressant effect of aqueous and ethanolic leave extracts of Lippia citriodora on postpartum depression in mice |
| title_sort | antidepressant effect of aqueous and ethanolic leave extracts of lippia citriodora on postpartum depression in mice |
| topic | depression forced-swim test lippia citriodora postpartum depression |
| url | https://ijogi.mums.ac.ir/article_19532_baa523cf4586439c713d598973f83b67.pdf |
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