Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming

Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming

Summary: Naked mole rat (NMR) is a valuable model for aging and cancer research due to its exceptional longevity and cancer resistance. We observed that the reprogramming efficiency of NMR fibroblasts in response to OSKM was drastically lower than that of mouse fibroblasts. Expression of SV40 LargeT...

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Bibliographic Details
Main Authors: Li Tan, Zhonghe Ke, Gregory Tombline, Nicholas Macoretta, Kevin Hayes, Xiao Tian, Ruitu Lv, Julia Ablaeva, Michael Gilbert, Natarajan V. Bhanu, Zuo-Fei Yuan, Benjamin A. Garcia, Yujiang G. Shi, Yang Shi, Andrei Seluanov, Vera Gorbunova
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117304332

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