Clinical and genetic characteristics in a central-southern Chinese cohort of early-onset Alzheimer's disease

Clinical and genetic characteristics in a central-southern Chinese cohort of early-onset Alzheimer's disease

BackgroundMutations in the presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) genes have been commonly identified in early-onset Alzheimer's disease (EOAD). Some of the mutations in the three causative genes, especially the PSEN1 gene, result in variable phenotypes...

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Bibliographic Details
Main Authors: Zhihou Liang, Yan Wu, Chuanzhou Li, Zhijun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neurology
Subjects:
early-onset AD
APP
PSEN1
PSEN2
phenotype heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1119326/full

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