Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/12/8689/ |
| _version_ | 1828474457969131520 |
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| author | Lihe Zhang Liangren Zhang Min Dong Jian Liu Kehui Zhang Zhenjun Yang Xiangchen Huang |
| author_facet | Lihe Zhang Liangren Zhang Min Dong Jian Liu Kehui Zhang Zhenjun Yang Xiangchen Huang |
| author_sort | Lihe Zhang |
| collection | DOAJ |
| description | A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system. |
| first_indexed | 2024-12-11T06:00:10Z |
| format | Article |
| id | doaj.art-5562f9da30a1451fad0e478af1e2063f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T06:00:10Z |
| publishDate | 2010-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5562f9da30a1451fad0e478af1e2063f2022-12-22T01:18:31ZengMDPI AGMolecules1420-30492010-11-0115128689870110.3390/molecules15128689Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPRLihe ZhangLiangren ZhangMin DongJian LiuKehui ZhangZhenjun YangXiangchen HuangA novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.http://www.mdpi.com/1420-3049/15/12/8689/cADPR analogueacyclic cADPR analoguetrifluoromethylationsynthesis |
| spellingShingle | Lihe Zhang Liangren Zhang Min Dong Jian Liu Kehui Zhang Zhenjun Yang Xiangchen Huang Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR Molecules cADPR analogue acyclic cADPR analogue trifluoromethylation synthesis |
| title | Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR |
| title_full | Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR |
| title_fullStr | Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR |
| title_full_unstemmed | Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR |
| title_short | Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR |
| title_sort | concise syntheses of trifluoromethylated cyclic and acyclic analogues of cadpr |
| topic | cADPR analogue acyclic cADPR analogue trifluoromethylation synthesis |
| url | http://www.mdpi.com/1420-3049/15/12/8689/ |
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