Mechanisms of ferroptosis in chronic kidney disease
Ferroptosis is a newly identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of numerous diseases and has emerged as a key area of focus in studies of chronic kidney disease (CKD). CKD is a major public...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.975582/full |
| _version_ | 1818496490687954944 |
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| author | Wen-Qing Zhuo Wen-Qing Zhuo Yi Wen Hui-Jun Luo Zhu-Lin Luo Li Wang Li Wang |
| author_facet | Wen-Qing Zhuo Wen-Qing Zhuo Yi Wen Hui-Jun Luo Zhu-Lin Luo Li Wang Li Wang |
| author_sort | Wen-Qing Zhuo |
| collection | DOAJ |
| description | Ferroptosis is a newly identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of numerous diseases and has emerged as a key area of focus in studies of chronic kidney disease (CKD). CKD is a major public health problem with high incidence and mortality that is characterized by a gradual loss of kidney function over time. The severity and complexity of CKD combined with the limited knowledge of its underlying molecular mechanism(s) have led to increased interest in this disease area. Here, we summarize recent advances in our understanding of the regulatory mechanism(s) of ferroptosis and highlight recent studies describing its role in the pathogenesis and progression of CKD. We further discuss the potential therapeutic benefits of targeting ferroptosis for the treatment of CKD and the major hurdles to overcome for the translation of in vitro studies into the clinic. |
| first_indexed | 2024-12-10T18:33:33Z |
| format | Article |
| id | doaj.art-5565e0a98a9c4fe1a22ad85cf721c69d |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-10T18:33:33Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-5565e0a98a9c4fe1a22ad85cf721c69d2022-12-22T01:37:53ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-08-01910.3389/fmolb.2022.975582975582Mechanisms of ferroptosis in chronic kidney diseaseWen-Qing Zhuo0Wen-Qing Zhuo1Yi Wen2Hui-Jun Luo3Zhu-Lin Luo4Li Wang5Li Wang6Department of Nephrology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaChinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, ChinaDepartment of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu, Sichuan, ChinaDepartment of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, United StatesDepartment of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command (Chengdu Military General Hospital), Chengdu, Sichuan, ChinaDepartment of Nephrology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaChinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, ChinaFerroptosis is a newly identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of numerous diseases and has emerged as a key area of focus in studies of chronic kidney disease (CKD). CKD is a major public health problem with high incidence and mortality that is characterized by a gradual loss of kidney function over time. The severity and complexity of CKD combined with the limited knowledge of its underlying molecular mechanism(s) have led to increased interest in this disease area. Here, we summarize recent advances in our understanding of the regulatory mechanism(s) of ferroptosis and highlight recent studies describing its role in the pathogenesis and progression of CKD. We further discuss the potential therapeutic benefits of targeting ferroptosis for the treatment of CKD and the major hurdles to overcome for the translation of in vitro studies into the clinic.https://www.frontiersin.org/articles/10.3389/fmolb.2022.975582/fullferroptosischronic kidney disease (CKD)regulatory genesreviewtherapeutic strategy |
| spellingShingle | Wen-Qing Zhuo Wen-Qing Zhuo Yi Wen Hui-Jun Luo Zhu-Lin Luo Li Wang Li Wang Mechanisms of ferroptosis in chronic kidney disease Frontiers in Molecular Biosciences ferroptosis chronic kidney disease (CKD) regulatory genes review therapeutic strategy |
| title | Mechanisms of ferroptosis in chronic kidney disease |
| title_full | Mechanisms of ferroptosis in chronic kidney disease |
| title_fullStr | Mechanisms of ferroptosis in chronic kidney disease |
| title_full_unstemmed | Mechanisms of ferroptosis in chronic kidney disease |
| title_short | Mechanisms of ferroptosis in chronic kidney disease |
| title_sort | mechanisms of ferroptosis in chronic kidney disease |
| topic | ferroptosis chronic kidney disease (CKD) regulatory genes review therapeutic strategy |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.975582/full |
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