Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer
Understanding metabolic and immune regulation inherent to patient populations is key to improving the radiation response for our patients. To date, radiation therapy regimens are prescribed based on tumor type and stage. Patient populations who are noted to have a poor response to radiation such as...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/1/175 |
| _version_ | 1797498873798721536 |
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| author | Anuradha A. Shastri Joseph Lombardo Samantha C. Okere Stephanie Higgins Brittany C. Smith Tiziana DeAngelis Ajay Palagani Kamryn Hines Daniel A. Monti Stella Volpe Edith P. Mitchell Nicole L. Simone |
| author_facet | Anuradha A. Shastri Joseph Lombardo Samantha C. Okere Stephanie Higgins Brittany C. Smith Tiziana DeAngelis Ajay Palagani Kamryn Hines Daniel A. Monti Stella Volpe Edith P. Mitchell Nicole L. Simone |
| author_sort | Anuradha A. Shastri |
| collection | DOAJ |
| description | Understanding metabolic and immune regulation inherent to patient populations is key to improving the radiation response for our patients. To date, radiation therapy regimens are prescribed based on tumor type and stage. Patient populations who are noted to have a poor response to radiation such as those of African American descent, those who have obesity or metabolic syndrome, or senior adult oncology patients, should be considered for concurrent therapies with radiation that will improve response. Here, we explore these populations of breast cancer patients, who frequently display radiation resistance and increased mortality rates, and identify the molecular underpinnings that are, in part, responsible for the radiation response and that result in an immune-suppressive tumor microenvironment. The resulting immune phenotype is discussed to understand how antitumor immunity could be improved. Correcting nutrient deficiencies observed in these populations should be considered as a means to improve the therapeutic index of radiation therapy. |
| first_indexed | 2024-03-10T03:39:31Z |
| format | Article |
| id | doaj.art-5565f8875f0945ac9b6ebba792d5f930 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:39:31Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5565f8875f0945ac9b6ebba792d5f9302023-11-23T11:35:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0123117510.3390/ijms23010175Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast CancerAnuradha A. Shastri0Joseph Lombardo1Samantha C. Okere2Stephanie Higgins3Brittany C. Smith4Tiziana DeAngelis5Ajay Palagani6Kamryn Hines7Daniel A. Monti8Stella Volpe9Edith P. Mitchell10Nicole L. Simone11Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Integrative Medicine and Nutritional Sciences, Marcus Institute of Integrative Health, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA 24061, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USAUnderstanding metabolic and immune regulation inherent to patient populations is key to improving the radiation response for our patients. To date, radiation therapy regimens are prescribed based on tumor type and stage. Patient populations who are noted to have a poor response to radiation such as those of African American descent, those who have obesity or metabolic syndrome, or senior adult oncology patients, should be considered for concurrent therapies with radiation that will improve response. Here, we explore these populations of breast cancer patients, who frequently display radiation resistance and increased mortality rates, and identify the molecular underpinnings that are, in part, responsible for the radiation response and that result in an immune-suppressive tumor microenvironment. The resulting immune phenotype is discussed to understand how antitumor immunity could be improved. Correcting nutrient deficiencies observed in these populations should be considered as a means to improve the therapeutic index of radiation therapy.https://www.mdpi.com/1422-0067/23/1/175breast cancerradiation therapynutrientAfrican Americanobesitymetabolic syndrome |
| spellingShingle | Anuradha A. Shastri Joseph Lombardo Samantha C. Okere Stephanie Higgins Brittany C. Smith Tiziana DeAngelis Ajay Palagani Kamryn Hines Daniel A. Monti Stella Volpe Edith P. Mitchell Nicole L. Simone Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer International Journal of Molecular Sciences breast cancer radiation therapy nutrient African American obesity metabolic syndrome |
| title | Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer |
| title_full | Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer |
| title_fullStr | Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer |
| title_full_unstemmed | Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer |
| title_short | Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer |
| title_sort | personalized nutrition as a key contributor to improving radiation response in breast cancer |
| topic | breast cancer radiation therapy nutrient African American obesity metabolic syndrome |
| url | https://www.mdpi.com/1422-0067/23/1/175 |
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