Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexes
SUMMARY: Intestinal Salmonella colonization of chickens represents one of the most important food safety hazards. Mitigating this problem is challenging since Salmonella is a commensal in poultry. In this study, we assessed the ability of proprietary zinc-amino acid and manganese-amino acid complexe...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Journal of Applied Poultry Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1056617123000600 |
| _version_ | 1797338350510669824 |
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| author | K. Anderson R. Burin M. Rebollo E. Krushinskie S. Dridi S. Carlson |
| author_facet | K. Anderson R. Burin M. Rebollo E. Krushinskie S. Dridi S. Carlson |
| author_sort | K. Anderson |
| collection | DOAJ |
| description | SUMMARY: Intestinal Salmonella colonization of chickens represents one of the most important food safety hazards. Mitigating this problem is challenging since Salmonella is a commensal in poultry. In this study, we assessed the ability of proprietary zinc-amino acid and manganese-amino acid complexes to reduce Salmonella colonization and shedding in commercial broilers receiving such trace minerals in the finisher diet. Broilers were orally challenged with Salmonella Typhimurium on 5 occasions between d 1 and d 20 of age. After confirming that the chicks were shedding Salmonella in the feces on d 22, broiler chicks were fed a standard diet containing: proprietary zinc-amino acid complexes; proprietary zinc- plus manganese-amino acids complexes; ZnSO4 + MnSO4; ZnSO4; or no additional supplements. Fecal samples were obtained on 4 occasions and were subjected to enumeration of Salmonella. Birds were euthanized on d 42 and ceca were removed for enumeration of Salmonella. Salmonella fecal shedding and cecal colonization were significantly decreased in broilers fed Zn-amino acid complexes, when compared to broilers fed Control diets. Feed efficiency and body weight gain were greater in broilers fed proprietary Zn-amino acid complexes or proprietary Zn- plus Mn-amino acids complexes compared to birds fed the Control or ZnSO4 + MnSO4 diets. Furthermore, real-time quantitative RT-PCR-based studies revealed enhanced expression of various cytokines, chemokines, tight junction proteins, and beta-defensins in birds fed the higher dose of the Zn-amino acid complexes. Thus, it appears that the Zn- and Mn-amino acid complexes reduce Salmonella carriage and improve feed efficiency possibly by optimizing the innate immune response to Salmonella and by improving gastrointestinal epithelial barrier. |
| first_indexed | 2024-03-08T09:29:52Z |
| format | Article |
| id | doaj.art-55664f7697ce410fb8a871bbc40244b8 |
| institution | Directory Open Access Journal |
| issn | 1056-6171 |
| language | English |
| last_indexed | 2024-03-08T09:29:52Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Applied Poultry Research |
| spelling | doaj.art-55664f7697ce410fb8a871bbc40244b82024-01-31T05:42:41ZengElsevierJournal of Applied Poultry Research1056-61712024-03-01331100388Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexesK. Anderson0R. Burin1M. Rebollo2E. Krushinskie3S. Dridi4S. Carlson5Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, USAZinpro Corporation, Eden Prairie, MN, USAZinpro Corporation, Eden Prairie, MN, USAFSRM Consulting LLC, Verona, VA, USACenter of Excellence for Poultry Science, University of Arkansas, Fayetteville, AR 72701, USADepartment of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA 50011, USA; Corresponding author:SUMMARY: Intestinal Salmonella colonization of chickens represents one of the most important food safety hazards. Mitigating this problem is challenging since Salmonella is a commensal in poultry. In this study, we assessed the ability of proprietary zinc-amino acid and manganese-amino acid complexes to reduce Salmonella colonization and shedding in commercial broilers receiving such trace minerals in the finisher diet. Broilers were orally challenged with Salmonella Typhimurium on 5 occasions between d 1 and d 20 of age. After confirming that the chicks were shedding Salmonella in the feces on d 22, broiler chicks were fed a standard diet containing: proprietary zinc-amino acid complexes; proprietary zinc- plus manganese-amino acids complexes; ZnSO4 + MnSO4; ZnSO4; or no additional supplements. Fecal samples were obtained on 4 occasions and were subjected to enumeration of Salmonella. Birds were euthanized on d 42 and ceca were removed for enumeration of Salmonella. Salmonella fecal shedding and cecal colonization were significantly decreased in broilers fed Zn-amino acid complexes, when compared to broilers fed Control diets. Feed efficiency and body weight gain were greater in broilers fed proprietary Zn-amino acid complexes or proprietary Zn- plus Mn-amino acids complexes compared to birds fed the Control or ZnSO4 + MnSO4 diets. Furthermore, real-time quantitative RT-PCR-based studies revealed enhanced expression of various cytokines, chemokines, tight junction proteins, and beta-defensins in birds fed the higher dose of the Zn-amino acid complexes. Thus, it appears that the Zn- and Mn-amino acid complexes reduce Salmonella carriage and improve feed efficiency possibly by optimizing the innate immune response to Salmonella and by improving gastrointestinal epithelial barrier.http://www.sciencedirect.com/science/article/pii/S1056617123000600Salmonellazincmanganesebroiler chicken |
| spellingShingle | K. Anderson R. Burin M. Rebollo E. Krushinskie S. Dridi S. Carlson Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexes Journal of Applied Poultry Research Salmonella zinc manganese broiler chicken |
| title | Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexes |
| title_full | Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexes |
| title_fullStr | Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexes |
| title_full_unstemmed | Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexes |
| title_short | Reduction of cecal colonization and fecal shedding of Salmonella Typhimurium in broilers fed proprietary zinc- or manganese-amino acid complexes |
| title_sort | reduction of cecal colonization and fecal shedding of salmonella typhimurium in broilers fed proprietary zinc or manganese amino acid complexes |
| topic | Salmonella zinc manganese broiler chicken |
| url | http://www.sciencedirect.com/science/article/pii/S1056617123000600 |
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