Papillary renal cell carcinoma with malakoplakia: A unique case
The reported cases of malakoplakia concurrent with renal cell carcinoma (RCC) are exceedingly rare. Two prior cases of malakoplakia have been previously reported in patients with clear cell renal cell carcinoma. We report the third case of concurrent malakoplakia and RCC in the same kidney and the f...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Human Pathology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772736X22000937 |
| _version_ | 1811297936045244416 |
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| author | Abigail A. Roth Ashmi Patel Haneen Salah Luan D. Truong Ziad M. El-Zaatari |
| author_facet | Abigail A. Roth Ashmi Patel Haneen Salah Luan D. Truong Ziad M. El-Zaatari |
| author_sort | Abigail A. Roth |
| collection | DOAJ |
| description | The reported cases of malakoplakia concurrent with renal cell carcinoma (RCC) are exceedingly rare. Two prior cases of malakoplakia have been previously reported in patients with clear cell renal cell carcinoma. We report the third case of concurrent malakoplakia and RCC in the same kidney and the first case of malakoplakia with the papillary type of renal cell carcinoma. Our case occurred in a 73-year-old woman with urinary tract infection and diabetes who was found to have a large renal mass on imaging and underwent radical nephrectomy. Malakoplakia was present both within the tumor and in portions of kidney away from the tumor itself. The microscopic features of malakoplakia included PAS-positive histiocytes with calcium positive Michaelis-Gutmann bodies which were also seen on electron microscopy. Since malakoplakia can mimic renal cell carcinomas (RCC) clinically and pathologically, our case highlights the importance of an awareness of the possible concurrence of these two diagnoses for accurate histopathologic diagnosis and treatment of patients with both diseases. |
| first_indexed | 2024-04-13T06:12:33Z |
| format | Article |
| id | doaj.art-556709452efd4b8da30df249e5850608 |
| institution | Directory Open Access Journal |
| issn | 2772-736X |
| language | English |
| last_indexed | 2024-04-13T06:12:33Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology Reports |
| spelling | doaj.art-556709452efd4b8da30df249e58506082022-12-22T02:58:58ZengElsevierHuman Pathology Reports2772-736X2022-11-0130300681Papillary renal cell carcinoma with malakoplakia: A unique caseAbigail A. Roth0Ashmi Patel1Haneen Salah2Luan D. Truong3Ziad M. El-Zaatari4Texas A&M School of Engineering Medicine, Houston, TX, United StatesTexas A&M School of Engineering Medicine, Houston, TX, United StatesDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United StatesDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United StatesDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United States; Corresponding author at: 6565 Fannin Street, Houston, TX 77030, United States.The reported cases of malakoplakia concurrent with renal cell carcinoma (RCC) are exceedingly rare. Two prior cases of malakoplakia have been previously reported in patients with clear cell renal cell carcinoma. We report the third case of concurrent malakoplakia and RCC in the same kidney and the first case of malakoplakia with the papillary type of renal cell carcinoma. Our case occurred in a 73-year-old woman with urinary tract infection and diabetes who was found to have a large renal mass on imaging and underwent radical nephrectomy. Malakoplakia was present both within the tumor and in portions of kidney away from the tumor itself. The microscopic features of malakoplakia included PAS-positive histiocytes with calcium positive Michaelis-Gutmann bodies which were also seen on electron microscopy. Since malakoplakia can mimic renal cell carcinomas (RCC) clinically and pathologically, our case highlights the importance of an awareness of the possible concurrence of these two diagnoses for accurate histopathologic diagnosis and treatment of patients with both diseases.http://www.sciencedirect.com/science/article/pii/S2772736X22000937MalakoplakiaRenal cell carcinomaPapillary renal cell carcinoma |
| spellingShingle | Abigail A. Roth Ashmi Patel Haneen Salah Luan D. Truong Ziad M. El-Zaatari Papillary renal cell carcinoma with malakoplakia: A unique case Human Pathology Reports Malakoplakia Renal cell carcinoma Papillary renal cell carcinoma |
| title | Papillary renal cell carcinoma with malakoplakia: A unique case |
| title_full | Papillary renal cell carcinoma with malakoplakia: A unique case |
| title_fullStr | Papillary renal cell carcinoma with malakoplakia: A unique case |
| title_full_unstemmed | Papillary renal cell carcinoma with malakoplakia: A unique case |
| title_short | Papillary renal cell carcinoma with malakoplakia: A unique case |
| title_sort | papillary renal cell carcinoma with malakoplakia a unique case |
| topic | Malakoplakia Renal cell carcinoma Papillary renal cell carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2772736X22000937 |
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