Three cases of scrub typhus with hemorrhage: a case report and literature review

Scrub typhus (ST) is an acute focal infectious disease that is caused by Orientia tsutsugamushi . The Asia-Pacific region is an area of relatively high incidence. There is a high incidence in China, principally owing to the disease being endemic in the south of the country. The main source of ST inf...

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Main Authors: Ziren Chen, Shi OuYang
Format: Article
Language:English
Published: SAGE Publishing 2023-10-01
Series:Journal of International Medical Research
Online Access:https://doi.org/10.1177/03000605231204430
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author Ziren Chen
Shi OuYang
author_facet Ziren Chen
Shi OuYang
author_sort Ziren Chen
collection DOAJ
description Scrub typhus (ST) is an acute focal infectious disease that is caused by Orientia tsutsugamushi . The Asia-Pacific region is an area of relatively high incidence. There is a high incidence in China, principally owing to the disease being endemic in the south of the country. The main source of ST infection is rats, which act as reservoirs of infection after being bitten by the chigger mite, and the human population is generally susceptible to the disease. ST can be controlled and treated successfully if antibiotics are administered in a timely manner. However, because it does not have a specific clinical manifestation, it is difficult to distinguish ST from other febrile diseases in clinical practice. Therefore, rapid diagnostic methods are still needed to help clinicians make a timely diagnosis. Here, we share three cases of patients with ST who experienced hemorrhage, but did not have typical skin lesions, such as eschar and ulcer, early in the course of their disease, and review the relevant literature regarding ST. We conclude that clinicians should pay attention to the risk of hemorrhage associated with this disease, and emphasize the importance of making an early diagnosis.
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spelling doaj.art-556847b15cae4c3dbed55f7b29acb2322023-10-28T01:03:55ZengSAGE PublishingJournal of International Medical Research1473-23002023-10-015110.1177/03000605231204430Three cases of scrub typhus with hemorrhage: a case report and literature reviewZiren ChenShi OuYangScrub typhus (ST) is an acute focal infectious disease that is caused by Orientia tsutsugamushi . The Asia-Pacific region is an area of relatively high incidence. There is a high incidence in China, principally owing to the disease being endemic in the south of the country. The main source of ST infection is rats, which act as reservoirs of infection after being bitten by the chigger mite, and the human population is generally susceptible to the disease. ST can be controlled and treated successfully if antibiotics are administered in a timely manner. However, because it does not have a specific clinical manifestation, it is difficult to distinguish ST from other febrile diseases in clinical practice. Therefore, rapid diagnostic methods are still needed to help clinicians make a timely diagnosis. Here, we share three cases of patients with ST who experienced hemorrhage, but did not have typical skin lesions, such as eschar and ulcer, early in the course of their disease, and review the relevant literature regarding ST. We conclude that clinicians should pay attention to the risk of hemorrhage associated with this disease, and emphasize the importance of making an early diagnosis.https://doi.org/10.1177/03000605231204430
spellingShingle Ziren Chen
Shi OuYang
Three cases of scrub typhus with hemorrhage: a case report and literature review
Journal of International Medical Research
title Three cases of scrub typhus with hemorrhage: a case report and literature review
title_full Three cases of scrub typhus with hemorrhage: a case report and literature review
title_fullStr Three cases of scrub typhus with hemorrhage: a case report and literature review
title_full_unstemmed Three cases of scrub typhus with hemorrhage: a case report and literature review
title_short Three cases of scrub typhus with hemorrhage: a case report and literature review
title_sort three cases of scrub typhus with hemorrhage a case report and literature review
url https://doi.org/10.1177/03000605231204430
work_keys_str_mv AT zirenchen threecasesofscrubtyphuswithhemorrhageacasereportandliteraturereview
AT shiouyang threecasesofscrubtyphuswithhemorrhageacasereportandliteraturereview