Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2026 |
| _version_ | 1797470364468510720 |
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| author | Dorina Amariucai-Mantu Violeta Mangalagiu Iustinian Bejan Aculina Aricu Ionel I. Mangalagiu |
| author_facet | Dorina Amariucai-Mantu Violeta Mangalagiu Iustinian Bejan Aculina Aricu Ionel I. Mangalagiu |
| author_sort | Dorina Amariucai-Mantu |
| collection | DOAJ |
| description | Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern antimicrobial therapy with very promising results including overcoming microbial drug resistance. The emphasis of this review is to notify the scientific community about the latest recent advances from the last five years in the field of hybrid azine derivatives with antimicrobial activity. The review is divided according to the main series of six-member ring azaheterocycles with one nitrogen atom and their fused analogs. In each case, the main essential data concerning synthesis and antimicrobial activity are presented. |
| first_indexed | 2024-03-09T19:35:31Z |
| format | Article |
| id | doaj.art-5568c6a3ea334d87973d77011972b106 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:35:31Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5568c6a3ea334d87973d77011972b1062023-11-24T01:54:08ZengMDPI AGPharmaceutics1999-49232022-09-011410202610.3390/pharmaceutics14102026Hybrid Azine Derivatives: A Useful Approach for Antimicrobial TherapyDorina Amariucai-Mantu0Violeta Mangalagiu1Iustinian Bejan2Aculina Aricu3Ionel I. Mangalagiu4Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, RomaniaCERNESIM Centre, Institute of Interdisciplinary Research, Alexandru Ioan Cuza University of Iasi, 11 Carol I, 700506 Iasi, RomaniaFaculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, RomaniaFaculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, RomaniaFaculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol 1st Bvd, 700506 Iasi, RomaniaNowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern antimicrobial therapy with very promising results including overcoming microbial drug resistance. The emphasis of this review is to notify the scientific community about the latest recent advances from the last five years in the field of hybrid azine derivatives with antimicrobial activity. The review is divided according to the main series of six-member ring azaheterocycles with one nitrogen atom and their fused analogs. In each case, the main essential data concerning synthesis and antimicrobial activity are presented.https://www.mdpi.com/1999-4923/14/10/2026hybrid compoundsantimicrobialpyridinequinolineisoquinolinefused azine |
| spellingShingle | Dorina Amariucai-Mantu Violeta Mangalagiu Iustinian Bejan Aculina Aricu Ionel I. Mangalagiu Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy Pharmaceutics hybrid compounds antimicrobial pyridine quinoline isoquinoline fused azine |
| title | Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy |
| title_full | Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy |
| title_fullStr | Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy |
| title_full_unstemmed | Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy |
| title_short | Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy |
| title_sort | hybrid azine derivatives a useful approach for antimicrobial therapy |
| topic | hybrid compounds antimicrobial pyridine quinoline isoquinoline fused azine |
| url | https://www.mdpi.com/1999-4923/14/10/2026 |
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