Ameliorative effect of hesperidin against high dose sildenafil-induced liver and testicular oxidative stress and altered gene expression in male rats

Ameliorative effect of hesperidin against high dose sildenafil-induced liver and testicular oxidative stress and altered gene expression in male rats

Abstract Background The clinical use of sildenafil citrate (Viagra), a drug used to treat erectile dysfunction, is limited because of its many side effects on tissues. In this context, we aimed to investigate the protective effects of hesperidin, a citrus flavonoid, on hepatic and testicular damage...

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Bibliographic Details
Main Authors: Ibrahim M. Ibrahim Laila, Samar HassabAllah Kassem, Marwa Salah ElDin Mohamed Diab
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Laboratory Animal Research
Subjects:
Sildenafil
Hesperidin
Oxidative stress
Antioxidants
Hepatotoxicity
Testicular toxicity
Online Access:https://doi.org/10.1186/s42826-023-00173-4

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