Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer’s disease (AD). The natural phthalide Ligustilide (LIG) has been demonstrated to protect against ag...

Full description

Bibliographic Details
Main Authors: Xi Kuang, Hong-Jing Zhou, Amy H. Thorne, Xi-Nan Chen, Lin-Jiao Li, Jun-Rong Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Ligustilide (LIG)
Klotho
APP
α-secretase processing
β-amyloid
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00353/full

Similar Items

Similar Items