A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder caused by germline mutation of the MEN1 gene. It is characterized by tumors of the anterior pituitary gland, parathyroid glands, and endocrine pancreas. Thymic carcinoid tumor is uncommon and associated with a hi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Yong Chan Lee
2019-03-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://helicojournal.org/upload/pdf/kjhugr-2019-19-1-65.pdf |
| _version_ | 1818670059442143232 |
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| author | Suk Ki Park Moon Won Lee In Sub Han Young Joo Park Sung Yong Han Joon Woo Park Bong Eun Lee Gwang Ha Kim Sang Soo Kim |
| author_facet | Suk Ki Park Moon Won Lee In Sub Han Young Joo Park Sung Yong Han Joon Woo Park Bong Eun Lee Gwang Ha Kim Sang Soo Kim |
| author_sort | Suk Ki Park |
| collection | DOAJ |
| description | Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder caused by germline mutation of the MEN1 gene. It is characterized by tumors of the anterior pituitary gland, parathyroid glands, and endocrine pancreas. Thymic carcinoid tumor is uncommon and associated with a high mortality, but its natural history has not been investigated yet. We report a case of asymptomatic MEN 1 with a thymic carcinoid tumor. A 37-year-old man underwent a routine medical checkup and upper gastrointestinal endoscopy revealed a duodenal neuroendocrine tumor (NET). Further studies showed the coexistence of pancreatic tumor, parathyroid hyperplasia, pituitary adenoma, and thymoma. The patient underwent duodenal endoscopic mucosal resection, distal pancreatectomy, subtotal parathyroidectomy, and thymectomy. The pathological test revealed a duodenal NET, pancreatic NET, parathyroid hyperplasia, and thymic carcinoid tumor. He was treated for MEN 1. We report this asymptomatic case of MEN 1 with a literature review. |
| first_indexed | 2024-12-17T07:02:05Z |
| format | Article |
| id | doaj.art-556aa3b327094d97b08301cf93b5737d |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-12-17T07:02:05Z |
| publishDate | 2019-03-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-556aa3b327094d97b08301cf93b5737d2022-12-21T21:59:15ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312019-03-01191657010.7704/kjhugr.2019.19.1.65550A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic CarcinoidSuk Ki Park0Moon Won Lee1In Sub Han2Young Joo Park3Sung Yong Han4Joon Woo Park5Bong Eun Lee6Gwang Ha Kim7Sang Soo Kim8Department of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaMultiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder caused by germline mutation of the MEN1 gene. It is characterized by tumors of the anterior pituitary gland, parathyroid glands, and endocrine pancreas. Thymic carcinoid tumor is uncommon and associated with a high mortality, but its natural history has not been investigated yet. We report a case of asymptomatic MEN 1 with a thymic carcinoid tumor. A 37-year-old man underwent a routine medical checkup and upper gastrointestinal endoscopy revealed a duodenal neuroendocrine tumor (NET). Further studies showed the coexistence of pancreatic tumor, parathyroid hyperplasia, pituitary adenoma, and thymoma. The patient underwent duodenal endoscopic mucosal resection, distal pancreatectomy, subtotal parathyroidectomy, and thymectomy. The pathological test revealed a duodenal NET, pancreatic NET, parathyroid hyperplasia, and thymic carcinoid tumor. He was treated for MEN 1. We report this asymptomatic case of MEN 1 with a literature review.http://helicojournal.org/upload/pdf/kjhugr-2019-19-1-65.pdfHyperparathyroidismMultiple endocrine neoplasia type 1Neuroendocrine tumorsThymoma |
| spellingShingle | Suk Ki Park Moon Won Lee In Sub Han Young Joo Park Sung Yong Han Joon Woo Park Bong Eun Lee Gwang Ha Kim Sang Soo Kim A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid The Korean Journal of Helicobacter and Upper Gastrointestinal Research Hyperparathyroidism Multiple endocrine neoplasia type 1 Neuroendocrine tumors Thymoma |
| title | A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid |
| title_full | A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid |
| title_fullStr | A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid |
| title_full_unstemmed | A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid |
| title_short | A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid |
| title_sort | case of asymptomatic multiple endocrine neoplasia type i with thymic carcinoid |
| topic | Hyperparathyroidism Multiple endocrine neoplasia type 1 Neuroendocrine tumors Thymoma |
| url | http://helicojournal.org/upload/pdf/kjhugr-2019-19-1-65.pdf |
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