Metal-Organic Framework (MOF)—A Universal Material for Biomedicine
Metal-organic frameworks (MOFs) are a very promising platform for applications in various industries. In recent years, a variety of methods have been developed for the preparation and modification of MOFs, providing a wide range of materials for different applications in life science. Despite the wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/9/7819 |
| _version_ | 1797602515102990336 |
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| author | Andrey A. Vodyashkin Antonina V. Sergorodceva Parfait Kezimana Yaroslav M. Stanishevskiy |
| author_facet | Andrey A. Vodyashkin Antonina V. Sergorodceva Parfait Kezimana Yaroslav M. Stanishevskiy |
| author_sort | Andrey A. Vodyashkin |
| collection | DOAJ |
| description | Metal-organic frameworks (MOFs) are a very promising platform for applications in various industries. In recent years, a variety of methods have been developed for the preparation and modification of MOFs, providing a wide range of materials for different applications in life science. Despite the wide range of different MOFs in terms of properties/sizes/chemical nature, they have not found wide application in biomedical practices at present. In this review, we look at the main methods for the preparation of MOFs that can ensure biomedical applications. In addition, we also review the available options for tuning the key parameters, such as size, morphology, and porosity, which are crucial for the use of MOFs in biomedical systems. This review also analyses possible applications for MOFs of different natures. Their high porosity allows the use of MOFs as universal carriers for different therapeutic molecules in the human body. The wide range of chemical species involved in the synthesis of MOFs makes it possible to enhance targeting and prolongation, as well as to create delivery systems that are sensitive to various factors. In addition, we also highlight how injectable, oral, and even ocular delivery systems based on MOFs can be used. The possibility of using MOFs as therapeutic agents and sensitizers in photodynamic, photothermal, and sonodynamic therapy was also reviewed. MOFs have demonstrated high selectivity in various diagnostic systems, making them promising for future applications. The present review aims to systematize the main ways of modifying MOFs, as well as the biomedical applications of various systems based on MOFs. |
| first_indexed | 2024-03-11T04:17:04Z |
| format | Article |
| id | doaj.art-556ca285ca84459a8c2a45521782547b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:17:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-556ca285ca84459a8c2a45521782547b2023-11-17T23:01:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01249781910.3390/ijms24097819Metal-Organic Framework (MOF)—A Universal Material for BiomedicineAndrey A. Vodyashkin0Antonina V. Sergorodceva1Parfait Kezimana2Yaroslav M. Stanishevskiy3Institute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., 117198 Moscow, RussiaInstitute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., 117198 Moscow, RussiaInstitute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., 117198 Moscow, RussiaInstitute of Biochemical Technology and Nanotechnology, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., 117198 Moscow, RussiaMetal-organic frameworks (MOFs) are a very promising platform for applications in various industries. In recent years, a variety of methods have been developed for the preparation and modification of MOFs, providing a wide range of materials for different applications in life science. Despite the wide range of different MOFs in terms of properties/sizes/chemical nature, they have not found wide application in biomedical practices at present. In this review, we look at the main methods for the preparation of MOFs that can ensure biomedical applications. In addition, we also review the available options for tuning the key parameters, such as size, morphology, and porosity, which are crucial for the use of MOFs in biomedical systems. This review also analyses possible applications for MOFs of different natures. Their high porosity allows the use of MOFs as universal carriers for different therapeutic molecules in the human body. The wide range of chemical species involved in the synthesis of MOFs makes it possible to enhance targeting and prolongation, as well as to create delivery systems that are sensitive to various factors. In addition, we also highlight how injectable, oral, and even ocular delivery systems based on MOFs can be used. The possibility of using MOFs as therapeutic agents and sensitizers in photodynamic, photothermal, and sonodynamic therapy was also reviewed. MOFs have demonstrated high selectivity in various diagnostic systems, making them promising for future applications. The present review aims to systematize the main ways of modifying MOFs, as well as the biomedical applications of various systems based on MOFs.https://www.mdpi.com/1422-0067/24/9/7819metal-organic frameworkssynthesis and post-synthetic modificationbiomedical applicationstargeted deliverydiagnostic systems |
| spellingShingle | Andrey A. Vodyashkin Antonina V. Sergorodceva Parfait Kezimana Yaroslav M. Stanishevskiy Metal-Organic Framework (MOF)—A Universal Material for Biomedicine International Journal of Molecular Sciences metal-organic frameworks synthesis and post-synthetic modification biomedical applications targeted delivery diagnostic systems |
| title | Metal-Organic Framework (MOF)—A Universal Material for Biomedicine |
| title_full | Metal-Organic Framework (MOF)—A Universal Material for Biomedicine |
| title_fullStr | Metal-Organic Framework (MOF)—A Universal Material for Biomedicine |
| title_full_unstemmed | Metal-Organic Framework (MOF)—A Universal Material for Biomedicine |
| title_short | Metal-Organic Framework (MOF)—A Universal Material for Biomedicine |
| title_sort | metal organic framework mof a universal material for biomedicine |
| topic | metal-organic frameworks synthesis and post-synthetic modification biomedical applications targeted delivery diagnostic systems |
| url | https://www.mdpi.com/1422-0067/24/9/7819 |
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