Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 t...

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Bibliographic Details
Main Authors: Reza Ghasemi, Eric Lazear, Xiaoli Wang, Saeed Arefanian, Alexander Zheleznyak, Beatriz M. Carreno, Ryuji Higashikubo, Andrew E. Gelman, Daniel Kreisel, Daved H. Fremont, Alexander Sasha Krupnick
Format: Article
Language:English
Published: Nature Portfolio 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12878

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