A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure
PurposeCoagulation disorder in congestive heart failure (CHF) has been well-documented. The prognostic value of a composite coagulation disorder score, which combines the absolute platelet count, international normalized ratio (INR), and activated partial thromboplastin time (APTT), has not been ass...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.999391/full |
| _version_ | 1811197409034764288 |
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| author | Yiyang Tang Qin Chen Benhui Liang Baohua Peng Meijuan Wang Jing Sun Zhenghui Liu Lihuang Zha Lihuang Zha Zaixin Yu Zaixin Yu |
| author_facet | Yiyang Tang Qin Chen Benhui Liang Baohua Peng Meijuan Wang Jing Sun Zhenghui Liu Lihuang Zha Lihuang Zha Zaixin Yu Zaixin Yu |
| author_sort | Yiyang Tang |
| collection | DOAJ |
| description | PurposeCoagulation disorder in congestive heart failure (CHF) has been well-documented. The prognostic value of a composite coagulation disorder score, which combines the absolute platelet count, international normalized ratio (INR), and activated partial thromboplastin time (APTT), has not been assessed in CHF. The present study endeavored to explore the association between the coagulation disorder score and adverse outcomes of critically ill patients with CHF.MethodsPatients diagnosed with CHF in the Medical Information Mart for Intensive Care III (MIMIC-III) database were included in the present retrospective cohort study. The coagulation disorder score was calculated according to the abnormalities of the absolute platelet count, INR, and APTT within 24 h after intensive care unit admission. The primary outcomes were the short-term all-cause mortality, including 30-, 90-day and in-hospital mortalities. The Kaplan–Meier (K-M) survival curve and the Cox proportional hazard model were performed to assess the correlation between coagulation disorder score and outcome events.ResultsA total of 6,895 patients were enrolled in this study and divided into four groups according to the coagulation disorder score. K-M survival curve preliminarily indicated that subjects with higher coagulation disorder score presented lower survival rate and shorter survival time. After adjustment for potential confounders, the multivariate Cox analysis further illustrated that elevated coagulation disorder score as a quartile variable was significantly associated with increased all-cause mortality (quartile 4 vs. quartile 1, 30-day: HR [95% CI], 1.98 [1.50, 2.62], 90-day: HR [95% CI], 1.88 [1.49, 2.37], in-hospital: HR [95%CI], 1.93 [1.42, 2.61]).ConclusionIn critically ill patients with CHF, ones with high coagulation disorder score tend to be worse clinical prognosis, which would be a promising biomarker and helpful for the management of CHF patients. |
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| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T01:13:17Z |
| publishDate | 2022-09-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-55707c78e26b454ebf691db3d2d2724b2022-12-22T03:54:02ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.999391999391A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failureYiyang Tang0Qin Chen1Benhui Liang2Baohua Peng3Meijuan Wang4Jing Sun5Zhenghui Liu6Lihuang Zha7Lihuang Zha8Zaixin Yu9Zaixin Yu10Department of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders (Xiang Ya), Changsha, ChinaDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders (Xiang Ya), Changsha, ChinaPurposeCoagulation disorder in congestive heart failure (CHF) has been well-documented. The prognostic value of a composite coagulation disorder score, which combines the absolute platelet count, international normalized ratio (INR), and activated partial thromboplastin time (APTT), has not been assessed in CHF. The present study endeavored to explore the association between the coagulation disorder score and adverse outcomes of critically ill patients with CHF.MethodsPatients diagnosed with CHF in the Medical Information Mart for Intensive Care III (MIMIC-III) database were included in the present retrospective cohort study. The coagulation disorder score was calculated according to the abnormalities of the absolute platelet count, INR, and APTT within 24 h after intensive care unit admission. The primary outcomes were the short-term all-cause mortality, including 30-, 90-day and in-hospital mortalities. The Kaplan–Meier (K-M) survival curve and the Cox proportional hazard model were performed to assess the correlation between coagulation disorder score and outcome events.ResultsA total of 6,895 patients were enrolled in this study and divided into four groups according to the coagulation disorder score. K-M survival curve preliminarily indicated that subjects with higher coagulation disorder score presented lower survival rate and shorter survival time. After adjustment for potential confounders, the multivariate Cox analysis further illustrated that elevated coagulation disorder score as a quartile variable was significantly associated with increased all-cause mortality (quartile 4 vs. quartile 1, 30-day: HR [95% CI], 1.98 [1.50, 2.62], 90-day: HR [95% CI], 1.88 [1.49, 2.37], in-hospital: HR [95%CI], 1.93 [1.42, 2.61]).ConclusionIn critically ill patients with CHF, ones with high coagulation disorder score tend to be worse clinical prognosis, which would be a promising biomarker and helpful for the management of CHF patients.https://www.frontiersin.org/articles/10.3389/fcvm.2022.999391/fullheart failurecoagulation disordermortalitybiomarkerMIMIC-III |
| spellingShingle | Yiyang Tang Qin Chen Benhui Liang Baohua Peng Meijuan Wang Jing Sun Zhenghui Liu Lihuang Zha Lihuang Zha Zaixin Yu Zaixin Yu A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure Frontiers in Cardiovascular Medicine heart failure coagulation disorder mortality biomarker MIMIC-III |
| title | A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure |
| title_full | A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure |
| title_fullStr | A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure |
| title_full_unstemmed | A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure |
| title_short | A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure |
| title_sort | retrospective cohort study on the association between early coagulation disorder and short term all cause mortality of critically ill patients with congestive heart failure |
| topic | heart failure coagulation disorder mortality biomarker MIMIC-III |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.999391/full |
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