Epigenetic mechanisms and stress coping in mood disorders
Introduction Experimental data from both clinical and preclinical studies have unequivocally shown positive correlations between stress and depression, stress, depression and epigenetic changes. Objectives The aim of this research is to analyze clinical trials on coping mechanisms and their intera...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2022-06-01
|
| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822005508/type/journal_article |
| _version_ | 1797616128087818240 |
|---|---|
| author | L. Hogea A.M. Ulucean L. Nussbaum |
| author_facet | L. Hogea A.M. Ulucean L. Nussbaum |
| author_sort | L. Hogea |
| collection | DOAJ |
| description |
Introduction
Experimental data from both clinical and preclinical studies have unequivocally shown positive correlations between stress and depression, stress, depression and epigenetic changes.
Objectives
The aim of this research is to analyze clinical trials on coping mechanisms and their interaction with epigenetic mechanisms in patients with mood disorders. Generally, we studied the interaction between these two mechanisms and its effects on the onset, recurrence and progression of these disorders.
Methods
109 articles were analyzed, of which 37 were considered relevant. 72 studies were excluded based on titles and abstracts. Regarding the coping mechanisms, 10 longitudinal and cross-sectional studies were selected. Longitudinal studies are defined here by a follow-up period longer than 6 months.
Results
There is a consistent association in the literature between the degree of methylation of the NR3C1 gene, stress and affectivity disorders. The analyzed studies showed that methylation of the NR3C1 gene is associated with both stress and mood disorders. FKBP5 influences glucocorticoid receptor sensitivity and stress response. SLC6A4 gene methylation has been systematically associated with stress and affectivity disorders. Higher BDNF methylation has also been found in people who report high levels of stress at work. The data collected suggest that SKA2 methylation may serve as a biomarker for certain features of depression, such as suicidal ideation, and is not directly involved in the etiology of mood disorders.
Conclusions
The results suggest that environmental stress and adversity in early childhood may change biological systems through epigenetic mechanisms and have long-term consequences, increasing the risk for unfavorable prognosis of mood disorders.
Disclosure
No significant relationships.
|
| first_indexed | 2024-03-11T07:36:52Z |
| format | Article |
| id | doaj.art-5570ccb6c0f4482295a2d5705e17e688 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:36:52Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-5570ccb6c0f4482295a2d5705e17e6882023-11-17T05:09:19ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S211S21110.1192/j.eurpsy.2022.550Epigenetic mechanisms and stress coping in mood disordersL. Hogea0A.M. Ulucean1L. Nussbaum2“Victor Babes” University of Medicine and Pharmacy, Department Of Neurosciences, Timisoara, Romania“Victor Babes” University of Medicine and Pharmacy, Department Of Neurosciences, Timisoara, Romania“Victor Babes” University of Medicine and Pharmacy, Department Of Neurosciences, Timisoara, Romania Introduction Experimental data from both clinical and preclinical studies have unequivocally shown positive correlations between stress and depression, stress, depression and epigenetic changes. Objectives The aim of this research is to analyze clinical trials on coping mechanisms and their interaction with epigenetic mechanisms in patients with mood disorders. Generally, we studied the interaction between these two mechanisms and its effects on the onset, recurrence and progression of these disorders. Methods 109 articles were analyzed, of which 37 were considered relevant. 72 studies were excluded based on titles and abstracts. Regarding the coping mechanisms, 10 longitudinal and cross-sectional studies were selected. Longitudinal studies are defined here by a follow-up period longer than 6 months. Results There is a consistent association in the literature between the degree of methylation of the NR3C1 gene, stress and affectivity disorders. The analyzed studies showed that methylation of the NR3C1 gene is associated with both stress and mood disorders. FKBP5 influences glucocorticoid receptor sensitivity and stress response. SLC6A4 gene methylation has been systematically associated with stress and affectivity disorders. Higher BDNF methylation has also been found in people who report high levels of stress at work. The data collected suggest that SKA2 methylation may serve as a biomarker for certain features of depression, such as suicidal ideation, and is not directly involved in the etiology of mood disorders. Conclusions The results suggest that environmental stress and adversity in early childhood may change biological systems through epigenetic mechanisms and have long-term consequences, increasing the risk for unfavorable prognosis of mood disorders. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822005508/type/journal_articlemood disordersstresscopingepigenetic |
| spellingShingle | L. Hogea A.M. Ulucean L. Nussbaum Epigenetic mechanisms and stress coping in mood disorders European Psychiatry mood disorders stress coping epigenetic |
| title | Epigenetic mechanisms and stress coping in mood disorders |
| title_full | Epigenetic mechanisms and stress coping in mood disorders |
| title_fullStr | Epigenetic mechanisms and stress coping in mood disorders |
| title_full_unstemmed | Epigenetic mechanisms and stress coping in mood disorders |
| title_short | Epigenetic mechanisms and stress coping in mood disorders |
| title_sort | epigenetic mechanisms and stress coping in mood disorders |
| topic | mood disorders stress coping epigenetic |
| url | https://www.cambridge.org/core/product/identifier/S0924933822005508/type/journal_article |
| work_keys_str_mv | AT lhogea epigeneticmechanismsandstresscopinginmooddisorders AT amulucean epigeneticmechanismsandstresscopinginmooddisorders AT lnussbaum epigeneticmechanismsandstresscopinginmooddisorders |