The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020
Prior non-comparative data showed increasing incidence of rectal neuroendocrine tumors (RNET) in the US. We aimed to evaluate age-specific RNET incidence rates and time-trends in demographic- and tumor-specific populations. The RNET age-adjusted incidence rates were calculated from the United States...
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/21/5286 |
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| author | Yazan Abboud Navya Pendyala Alexander Le Anmol Mittal Saqr Alsakarneh Fouad Jaber Kaveh Hajifathalian |
| author_facet | Yazan Abboud Navya Pendyala Alexander Le Anmol Mittal Saqr Alsakarneh Fouad Jaber Kaveh Hajifathalian |
| author_sort | Yazan Abboud |
| collection | DOAJ |
| description | Prior non-comparative data showed increasing incidence of rectal neuroendocrine tumors (RNET) in the US. We aimed to evaluate age-specific RNET incidence rates and time-trends in demographic- and tumor-specific populations. The RNET age-adjusted incidence rates were calculated from the United States Cancer Statistics (USCS) database between 2001 and 2020. The population was stratified by age into older (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>≥</mo></mrow></semantics></math></inline-formula>55 years) and younger adults (<55 years), as well as by sex and race. The tumors were categorized by their stage at diagnosis into early and late. The annual percentage change (APC) and average APC (AAPC) were estimated using joinpoint regression and Monte Carlo permutation analysis. Pairwise comparison assessed for parallelism and coincidence. There were 59,846 patients diagnosed with RNET between 2001 and 2020 (50.3% women). Overall, the RNET incidence rates during this period were increasing in younger but not older adults (AAPC = 3.12 vs. −1.10; AAPC difference = 4.22, <i>p</i> < 0.001), with non-identical non-parallel data (<i>p</i>-values < 0.001). While similar results were seen in men, a greater age-specific difference was noted in women (AAPC = 3.31 vs. −1.10; AAPC difference = 4.41, <i>p</i> = 0.003). The difference between younger and older adults was seen in non-Hispanic White (AAPC-difference = 4.89; <i>p</i> < 0.001) and non-Hispanic Black (AAPC-difference = 3.33; <i>p</i> = 0.03) patients, and, in most years, among Hispanic and Non-Hispanic Asian/Pacific Islander patients, and it was mostly driven by early-stage tumors (AAPC-difference = 3.93; <i>p</i> < 0.001). The nationwide data show a significantly increasing RNET incidence in younger adults, most notably in younger women and in early-stage tumors, seen in various races. Future studies should evaluate RNET risk factors and outcomes in demographic-specific populations. |
| first_indexed | 2024-03-11T11:32:33Z |
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| id | doaj.art-55716a57af1c46f192f74b7f66dfc2b4 |
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| language | English |
| last_indexed | 2024-03-11T11:32:33Z |
| publishDate | 2023-11-01 |
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| spelling | doaj.art-55716a57af1c46f192f74b7f66dfc2b42023-11-10T15:00:30ZengMDPI AGCancers2072-66942023-11-011521528610.3390/cancers15215286The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020Yazan Abboud0Navya Pendyala1Alexander Le2Anmol Mittal3Saqr Alsakarneh4Fouad Jaber5Kaveh Hajifathalian6Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USADepartment of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USADepartment of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USADepartment of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USADepartment of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USADepartment of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USADivision of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USAPrior non-comparative data showed increasing incidence of rectal neuroendocrine tumors (RNET) in the US. We aimed to evaluate age-specific RNET incidence rates and time-trends in demographic- and tumor-specific populations. The RNET age-adjusted incidence rates were calculated from the United States Cancer Statistics (USCS) database between 2001 and 2020. The population was stratified by age into older (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>≥</mo></mrow></semantics></math></inline-formula>55 years) and younger adults (<55 years), as well as by sex and race. The tumors were categorized by their stage at diagnosis into early and late. The annual percentage change (APC) and average APC (AAPC) were estimated using joinpoint regression and Monte Carlo permutation analysis. Pairwise comparison assessed for parallelism and coincidence. There were 59,846 patients diagnosed with RNET between 2001 and 2020 (50.3% women). Overall, the RNET incidence rates during this period were increasing in younger but not older adults (AAPC = 3.12 vs. −1.10; AAPC difference = 4.22, <i>p</i> < 0.001), with non-identical non-parallel data (<i>p</i>-values < 0.001). While similar results were seen in men, a greater age-specific difference was noted in women (AAPC = 3.31 vs. −1.10; AAPC difference = 4.41, <i>p</i> = 0.003). The difference between younger and older adults was seen in non-Hispanic White (AAPC-difference = 4.89; <i>p</i> < 0.001) and non-Hispanic Black (AAPC-difference = 3.33; <i>p</i> = 0.03) patients, and, in most years, among Hispanic and Non-Hispanic Asian/Pacific Islander patients, and it was mostly driven by early-stage tumors (AAPC-difference = 3.93; <i>p</i> < 0.001). The nationwide data show a significantly increasing RNET incidence in younger adults, most notably in younger women and in early-stage tumors, seen in various races. Future studies should evaluate RNET risk factors and outcomes in demographic-specific populations.https://www.mdpi.com/2072-6694/15/21/5286rectal neuroendocrine tumorsincidenceepidemiologyrectal cancerhealth disparityneuroendocrine tumors |
| spellingShingle | Yazan Abboud Navya Pendyala Alexander Le Anmol Mittal Saqr Alsakarneh Fouad Jaber Kaveh Hajifathalian The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020 Cancers rectal neuroendocrine tumors incidence epidemiology rectal cancer health disparity neuroendocrine tumors |
| title | The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020 |
| title_full | The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020 |
| title_fullStr | The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020 |
| title_full_unstemmed | The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020 |
| title_short | The Incidence of Rectal Neuroendocrine Tumors Is Increasing in Younger Adults in the US, 2001–2020 |
| title_sort | incidence of rectal neuroendocrine tumors is increasing in younger adults in the us 2001 2020 |
| topic | rectal neuroendocrine tumors incidence epidemiology rectal cancer health disparity neuroendocrine tumors |
| url | https://www.mdpi.com/2072-6694/15/21/5286 |
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