Intradermal Delivery of Dendritic Cell-Targeting Chimeric mAbs Genetically Fused to Type 2 Dengue Virus Nonstructural Protein 1

Intradermal Delivery of Dendritic Cell-Targeting Chimeric mAbs Genetically Fused to Type 2 Dengue Virus Nonstructural Protein 1

Targeting dendritic cells (DCs) by means of monoclonal antibodies (mAbs) capable of binding their surface receptors (DEC205 and DCIR2) has previously been shown to enhance the immunogenicity of genetically fused antigens. This approach has been repeatedly demonstrated to enhance the induced immune r...

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Bibliographic Details
Main Authors: Lennon Ramos Pereira, Elaine Cristina Matos Vicentin, Sara Araujo Pereira, Denicar Lina Nascimento Fabris Maeda, Rúbens Prince dos Santos Alves, Robert Andreata-Santos, Francielle Tramontini Gomes de Sousa, Marcio Massao Yamamoto, Maria Fernanda Castro-Amarante, Marianna Teixeira de Pinho Favaro, Camila Malta Romano, Ester Cerdeira Sabino, Silvia Beatriz Boscardin, Luís Carlos de Souza Ferreira
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Vaccines
Subjects:
intradermal
DEC205
DCIR2
dendritic cell
NS1 protein
Dengue virus
Online Access:https://www.mdpi.com/2076-393X/8/4/565

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