Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells

Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells

Ovarian cancer (OC) is one of the most common gynecologic neoplasia and has the highest mortality rate, which is mainly due to late-stage diagnosis and chemotherapy resistance. There is an urgent need to explore new and better therapeutic strategies. We have previously described a family of Microtub...

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Bibliographic Details
Main Authors: María Ovejero-Sánchez, Gloria Asensio-Juárez, Myriam González, Pilar Puebla, Miguel Vicente-Manzanares, Rafael Pélaez, Rogelio González-Sarmiento, Ana Belén Herrero
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
panobinostat
microtubule-destabilizing agents
tubulin
acetylation
Online Access:https://www.mdpi.com/1422-0067/23/21/13019

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